Back to Journals » OncoTargets and Therapy » Volume 11

The application of a three-dimensional visualized seed planning and navigation system in 125I seed implantation for pancreatic cancer

Authors Hu YY, Qi EP, Liu FY, Lu YH, Tan SL, Sun Y, Han ZY, Liang P, Yu XL

Received 6 May 2017

Accepted for publication 3 August 2017

Published 31 January 2018 Volume 2018:11 Pages 619—627

DOI https://doi.org/10.2147/OTT.S141245

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Amy Norman

Peer reviewer comments 2

Editor who approved publication: Dr Samir Farghaly


Yanyan Hu,1,2 Erpeng Qi,1 Fangyi Liu,1 Yuhan Lu,1 Shuilian Tan,1 Ya Sun,1 Zhiyu Han,1 Ping Liang,1 Xiaoling Yu1

1Department of Interventional Ultrasound, General Hospital of People’s Liberation Army, Beijing, China; 2Medical Department, First Affiliated Hospital of PLA General Hospital, Beijing, China

Objectives: To evaluate the effectiveness of iodine-125 (125I) seed implantation for pancreatic cancer (PC), and preliminarily evaluate the clinical value of a self-developed three-dimensional (3D) visualized seed planning and navigation system in 125I seed implantation for treatment of PC.
Patients and methods: Our team retrospectively reviewed 25 PC patients who underwent 125I seed implantation between December 2010 and November 2016. The patients were divided into two groups: 3D visualization preoperative planning group (12 patients, 13 lesions) and two-dimensional (2D) regular group (13 patients, 14 lesions). We compared and analyzed the parameters of the two groups, such as number of needle insertions, one-time treatment success rate, proportion of added seeds, local control rate, rate of complications, rate of pain relief, and the survival rate and risk factors of the two groups. There was no significant difference in clinical data of the two groups.
Results: 125I seed implantation was performed successfully in all PC patients, with no occurrence of serious complications during and after the procedure. The one-time treatment success rate of 3D group (80%) was higher than that of 2D group (45.5%) (P<0.05), and the proportion of added seed number of 3D group was lower than that of 2D group (P<0.05). The local control rate of 3D group (76.9%) was higher than that of 2D group (35.7%) (P<0.05). The survival rate of 3D group was significantly higher than that of 2D group (P=0.026), and the median survival of 2D group vs 3D group was 5.00 vs 10.80 months. The median survival of all 25 patients was 7.10 months (95% confidence interval: 4.43–9.77). The rate of pain relief was 77.8% (7/9) in 2D group and 88.9% (8/9) in 3D group.
Conclusion: Ultrasound-guided, 3D visualized seed planning and navigation system assisted 125I seed implantation is a safe and effective method for the treatment of PC, with a prolonged survival of patients and better local control of tumor.

Keywords: 125I seed, pancreatic cancer, intraoperative implantation, ultrasound-guided, three-dimensional visualization

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]