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The Antimicrobial Peptide Melectin Shows Both Antimicrobial and Antitumor Activity via Membrane Interference and DNA Binding

Authors Liang X, Yan J, Lu Y, Liu S, Chai X

Received 30 October 2020

Accepted for publication 5 February 2021

Published 19 March 2021 Volume 2021:15 Pages 1261—1273

DOI https://doi.org/10.2147/DDDT.S288219

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Anastasios Lymperopoulos


Xiaolei Liang,1,* Jiexi Yan,2,* Yingwei Lu,3 Shan Liu,4 Xiaojing Chai5

1Key Laboratory for Gynecologic Oncology Gansu Province, Department of Obstetrics and Gynecology, The First Hospital of Lanzhou University, Lanzhou, People’s Republic of China; 2The Precision Medicine Laboratory, The First Hospital of Lanzhou University, Lanzhou, People’s Republic of China; 3Gansu Provincial Center for Disease Control and Prevention, Lanzhou, People’s Republic of China; 4The First Clinical Medicine School, Lanzhou University, Lanzhou, People’s Republic of China; 5The Key Laboratory, The First Hospital of Lanzhou University, Lanzhou, People’s Republic of China

*These authors contributed equally to this work

Correspondence: Xiaojing Chai
The Key Laboratory, The First Hospital of Lanzhou University, No. 1, Donggang Road, Lanzhou, People’s Republic of China
Email [email protected]

Purpose: Increasingly complex diseases require novel drugs for their treatment. Antimicrobial peptides (AMPs) are promising candidate treatments due to their broad existence and special characteristics. However, the current understanding of AMPs is not sufficient to allow them to be produced commercially for clinical use.
Materials and Methods: Melectin, from the venom of the cleptoparasitic bee Melecta albifrons, does not exhibit sequence homology with other wasp venom peptides. To investigate this more deeply, we explored the antibacterial and antitumor activities of Melectin and related mechanisms.
Results: Our results demonstrate that Melectin possesses antimicrobial properties against standard sensitive/clinical drug-resistant bacteria strains as well as antitumor activity. It has an α-helix form and exhibits moderate cytotoxicity. Its action mechanisms are involved with membrane interfering and DNA binding. The membrane interfering effect was distinct between different phospholipid compositions.
Conclusion: We found that Melectin may serve as a new potential template in the battle against multidrug resistance, and our study indicated that there are promising prospects for medically applicable drugs based on AMPs.

Keywords: antimicrobial peptide, melectin, antibacterial, antitumor, action mechanism

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