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The Anti-Cancer Mechanisms of Berberine: A Review

Authors Wang Y, Liu Y, Du X, Ma H, Yao J

Received 13 December 2019

Accepted for publication 22 January 2020

Published 30 January 2020 Volume 2020:12 Pages 695—702

DOI https://doi.org/10.2147/CMAR.S242329

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Antonella D'Anneo


Ye Wang,* Yanfang Liu,* Xinyang Du, Hong Ma, Jing Yao

Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, People’s Republic of China

*These authors contributed equally to this work

Correspondence: Jing Yao
Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Road 1277, Wuhan 430022, Hubei Province, People’s Republic of China
Tel +86-18986271157
Email 2007XH0839@hust.edu.cn

Abstract: Berberine (BBR) has been extensively studied in vivo and vitro experiments. BBR inhibits cell proliferation by regulating cell cycle and cell autophagy, and promoting cell apoptosis. BBR also inhibits cell invasion and metastasis by suppressing EMT and down-regulating the expression of metastasis-related proteins and signaling pathways. In addition, BBR inhibits cell proliferation by interacting with microRNAs and suppressing telomerase activity. BBR exerts its anti-inflammation and antioxidant properties, and also regulates tumor microenvironment. This review emphasized that BBR as a potential anti-inflammation and antioxidant agent, also as an effective immunomodulator, is expected to be widely used in clinic for cancer therapy.

Keywords: berberine, anti-tumor, traditional Chinese medicine, cancer


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