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The -1082 A allele of the interleukin-10 single nucleotide polymorphism -1082 G/A is associated with hepatitis virus co-infection in Indonesian Javanese HIV patients

Authors Prasetyo AA, Nurfitria FB, Adnan ZA, Redhono D, Sari Y, Hudiyono

Received 12 February 2015

Accepted for publication 16 April 2015

Published 16 June 2015 Volume 2015:7 Pages 1—7


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Dr Randall Davis

Afiono Agung Prasetyo,1–3 Fadhila Balqis Nurfitria,1 Zainal Arifin Adnan,1,4 Dhani Redhono,4 Yulia Sari,1,2,5 Hudiyono1–3
1A-IGIC Research Group Faculty of Medicine, 2Center of Biotechnology and Biodiversity Research and Development, 3Department of Microbiology, 4Department of Internal Medicine, 5Department of Parasitology, Faculty of Medicine, Sebelas Maret University, Surakarta, Indonesia

Objective: This study was conducted to determine the distribution of the single nucleotide polymorphism (SNP) at position -1082 of the proximal promoter region of the interleukin (IL)-10 gene and its association with hepatitis virus co-infection in Indonesian Javanese human immunodeficiency virus (HIV)-infected patients.
Methods: Blood samples were collected from 156 Indonesian Javanese HIV-infected patients; tested with serological and molecular assays for hepatitis B virus (HBV), hepatitis C virus (HCV), and hepatitis D virus (HDV); and subjected to SNP -1082 G/A polymorphism analysis.
Results: Hepatitis B surface antigen (HBsAg) (+)/HBV DNA (+), HBsAg (-)/HBV DNA (+), anti-HCV antibodies (+)/HCV RNA (+), and anti-HCV antibodies (-)/HCV RNA (+) were detected from all of HIV-infected individuals at rates of 3.8% (6/156), 0.6% (1/156), 16.0% (25/156), and 11.5% (18/156), respectively. The frequencies of -1082 GG, -1082 GA, and -1082 AA were 14.7% (23/156), 60.3% (94/156), and 25% (39/156), respectively. HBV co-infection was found only in -1082 A allele carriers, and these patients also showed higher rates of HCV co-infection (odds ratio: 2.24, 95% confidence interval: 1.22–4.10, P=0.009).
Conclusion: The -1082 A allele was associated with HBV and HCV co-infection in Indonesian Javanese HIV patients.

Keywords: IL-10 -1082, HIV, HBV, HCV, Indonesia

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