Back to Journals » Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy » Volume 11

Testosterone, obesity, and waist circumference as determinants of metabolic syndrome in Saudi women

Authors Fatani SH, Abdelbasit NA, Al-Amodi HS, Mukhtar MM, Babakr AT

Received 3 November 2017

Accepted for publication 25 January 2018

Published 1 May 2018 Volume 2018:11 Pages 175—181


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Professor Ming-Hui Zou

Sameer H Fatani,1 Nazik Altayeb Abdelbasit,1 Hiba S Al-Amodi,1 Maowia Mohamed Mukhtar,2 Abdullatif Taha Babakr1

1Department of Medical Biochemistry, Faculty of Medicine, Umm Al-Qura University, Makkah, Kingdom of Saudi Arabia; 2Department of Molecular Biology, Institute of Endemic Diseases, University of Khartoum, Medical Campus, Khartoum, Sudan

High serum total testosterone is associated with metabolic syndrome (MS). This study aimed to identify possible alterations in total testosterone and their relationship with plasma glucose, blood pressure, and serum lipid profile.
Methods: One hundred forty-two female subjects were selected to participate in this study, and they were recruited by consultant physicians from the Clinic and Medical Out-Patient, King Abdulaziz Hospital, Kingdom of Saudi Arabia. The anthropometric characteristics were obtained from questionnaires by using standard methods. Blood samples were obtained for the determination of glucose, triglycerides, total cholesterol, low-density lipoprotein, and high-density lipoprotein by using enzymatic methods. Total testosterone was determined by enzyme-linked immunosorbent assay for the quantitative measurement of testosterone in human serum.
Results: Significantly higher concentrations of total testosterone, low-density lipoprotein, and glucose, but lower concentrations of high-density lipoprotein, were observed in subjects with MS compared with women without MS (P<0.05).
Conclusion: This study suggests that high levels of total testosterone and disturbance in lipid profile were associated with MS in Saudi women.

Keywords: obesity, hyperlipidemia, testosterone, metabolic syndrome, lipid profile, androgen, insulin resistance

A Letter to the Editor has been received and published for this article.

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]