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Tension Pneumocephalus from Endoscopic Endonasal Surgery: A Case Series and Literature Review

Authors Li W, Liu Q, Lu H, Wang H, Zhang H, Hu L, Sun X, Gu Y, Li H, Zhao W, Wang D

Received 24 April 2020

Accepted for publication 7 June 2020

Published 19 June 2020 Volume 2020:16 Pages 531—538


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Professor Deyun Wang

Wanpeng Li,* Quan Liu,* Hanyu Lu, Huan Wang, Huankang Zhang, Li Hu, Xicai Sun, Yurong Gu, Houyong Li, Weidong Zhao, Dehui Wang

Department of Otolaryngology-Head and Neck Surgery, Affiliated Eye Ear Nose and Throat Hospital, Fudan University, Shanghai 200031, People’s Republic of China

*These authors contributed equally to this work

Correspondence: Weidong Zhao; Dehui Wang Email;

Purpose: Tension pneumocephalus (TP) caused by endoscopic endonasal surgery is a serious complication. We report four cases of TP caused by endoscopic surgery and review other cases in the literature, with special attention devoted to symptoms, imaging features, and therapeutic approaches.
Methods: A retrospective chart review of patients who experienced TP caused by endoscopic surgery in our institution between 2015 and 2018 was performed. Additionally, the MEDLINE database was searched for all case series or reports of TP caused by endoscopic surgery.
Results: Eighteen articles were identified for review, including four cases from the authors’ institution; ultimately, 26 cases were included in the present study. The main symptoms of TP were headache and a change in mental status. Cerebrospinal fluid (CSF) leakage was reported in 21 of the 26 patients (80.8%). Eight of the 26 patients (30.8%) presented with the “Mount Fuji sign” imaging feature. Twenty-four patients were treated with surgical intervention for TP (endoscopic multilayer closure of skull base defect, cranial burr hole, or bifrontal craniotomy). In addition, the present study is the first to report two patients with TP who were successfully treated conservatively.
Conclusion: The therapeutic method for treating TP should depend on the degree of the mass effect and clinical symptoms. When patients with TP present with obvious symptoms of CSF leakage and intracranial hypertension, urgent surgical multilayer repair of the skull base defects and/or release of the intracranial pressure are keys to treating these patients. However, conservative treatment under close observation is also feasible when the related symptoms are not overtly obvious.

Keywords: tension pneumocephalus, endoscopic surgery, cerebrospinal fluid, skull base

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