Technological innovations for clinical sample storage in a Swedish Cervical Cytology Biobank: a review
1Division of Laboratory Medicine, Department of Pathology, Karolinska Institute, 2Laboratory of Clinical Pathology–Cytology, Karolinska University Hospital, Huddinge, Stockholm, Sweden
Abstract: The biological samples collected from women who have participated in cervical cancer screening constitute huge cohorts, providing the necessary statistical power to aid researchers in translating basic scientific discoveries into clinical applications. The availability of high-quality cytological specimens for diagnostic and research purposes requires the development of standardized methods for sample handling and long-term storage to enable the future use of specimens. The Swedish Cervical Cytology Biobank (SCCB) is an innovative solution for the biopreservation of gynecological cell samples. SCCB is the first national initiative for a prospective repository of liquid-based gynecological cell samples from women participating in organized and nonorganized cervical cancer screening. The successful nationalization of the SCCB is based on the three vital issues: 1) the system's flexibility to adapt to other regional systems; 2) system development, as based on a national collaboration between the university and county councils; and 3) stable government financing by the provider, BBMRI.se. The greatest advantage of a nationalized biobanking infrastructure is the tremendous potential to perform high-quality, multicenter research using the biobank's samples and the samples' national clinical records. We intend to share our experiences with biorepository communities to promote an understanding of and advances in opportunities to establish a disease-oriented and population-based biobank that covers the health care needs of the entire nation.
Keywords: cervical cytology, automation solutions, national collaboration
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