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Tattoo removal with ingenol mebutate

Authors Cozzi SJ, Le TT, Ogbourne SM, James C, Suhrbier A

Received 27 February 2017

Accepted for publication 5 April 2017

Published 25 May 2017 Volume 2017:10 Pages 205—210


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Jeffrey Weinberg

Sarah-Jane Cozzi,1 Thuy T Le,1 Steven M Ogbourne,2 Cini James,1 Andreas Suhrbier1

1Inflammation Biology Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, 2Genecology Research Center, Faculty of Science, Health, Engineering and Education, University of the Sunshine Coast, Maroochydore DC, QLD, Australia

Abstract: An increasing number of people are getting tattoos; however, many regret the decision and seek their removal. Lasers are currently the most commonly used method for tattoo removal; however, treatment can be lengthy, costly, and sometimes ineffective, especially for certain colors. Ingenol mebutate is a licensed topical treatment for actinic keratoses. Here, we demonstrate that two applications of 0.1% ingenol mebutate can efficiently and consistently remove 2-week-old tattoos from SKH/hr hairless mice. Treatment was associated with relocation of tattoo microspheres from the dermis into the posttreatment eschar. The skin lesion resolved about 20 days after treatment initiation, with some cicatrix formation evident. The implications for using ingenol mebutate for tattoo removal in humans are discussed.

Keywords: tattoo, ingenol mebutate, mouse

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