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Targeting the androgen receptor in triple-negative breast cancer: current perspectives

Authors Mina A, Yoder R, Sharma P

Received 29 June 2017

Accepted for publication 30 August 2017

Published 20 September 2017 Volume 2017:10 Pages 4675—4685

DOI https://doi.org/10.2147/OTT.S126051

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 7

Editor who approved publication: Dr XuYu Yang

Alain Mina,1 Rachel Yoder,2 Priyanka Sharma1

1Division of Medical Oncology, Department of Internal Medicine, University of Kansas Medical Center, Westwood, 2University of Kansas Cancer Center, Kansas City, KS, USA

Abstract: Triple-negative breast cancer (TNBC) is an aggressive subtype associated with frequent recurrence and metastasis. Unlike hormone receptor-positive subtypes, treatment of TNBC is currently limited by the lack of clinically available targeted therapies. Androgen signaling is necessary for normal breast development, and its dysregulation has been implicated in breast tumorigenesis. In recent years, gene expression studies have identified a subset of TNBC that is enriched for androgen receptor (AR) signaling. Interference with androgen signaling in TNBC is promising, and AR-inhibiting drugs have shown antitumorigenic activity in preclinical and proof of concept clinical studies. Recent advances in our understanding of androgenic signaling in TNBC, along with the identification of interacting pathways, are allowing development of the next generation of clinical trials with AR inhibitors. As novel AR-targeting agents are developed and evaluated in clinical trials, it is equally important to establish a robust set of biomarkers for identification of TNBC tumors that are most likely to respond to AR inhibition.

Keywords: triple-negative breast cancer, androgen signaling, targeted therapy, biomarkers, prognosis
 

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