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Targeting Cardiac Metabolic Pathways: A Role in Ischemic Management

Authors Yehualashet AS, Belachew TF, Kifle ZD, Abebe AM

Received 29 May 2020

Accepted for publication 11 August 2020

Published 14 September 2020 Volume 2020:16 Pages 353—365

DOI https://doi.org/10.2147/VHRM.S264130

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Dr Takashi Kajiya


Awgichew Shewasinad Yehualashet,1 Teshome Fentik Belachew,2 Zemene Demelash Kifle,3 Ayele Mamo Abebe4

1Pharmacology and Toxicology Unit, Department of Pharmacy, College of Health Sciences, Debre Berhan University, Debre Berhan, Ethiopia; 2Department of Pharmacy, Debre Birhan Health Science College, Debre Birhan, Ethiopia; 3School of Pharmacy, Department of Pharmacology, University of Gondar, Gondar, Ethiopia; 4Department of Nursing, College of Health Sciences, Debre Berhan University, Debre Berhan, Ethiopia

Correspondence: Awgichew Shewasinad Yehualashet
Pharmacology and Toxicology Unit, Department of Pharmacy, College of Health Sciences, Debre Berhan University, PO Box 445, Debre Berhan, Ethiopia
Tel +251-93-545-0290
Email awgshewa@gmail.com

Abstract: Among the vast number of noncommunicable diseases encountered worldwide, cardiovascular diseases accounted for about 17.8 million deaths in 2017 and ischemic heart disease (IHD) remains the single-largest cause of death in countries across all income groups. Because conventional medications are not without shortcomings and patients still refractory to these medications, scientific investigation is ongoing to advance the management of IHD, and shows a great promise for better treatment modalities, but additional research can warrant improvement in terms of the quality of life of patients. Metabolic modulation is one promising strategy for the treatment of IHD, because alterations in energy metabolism are involved in progression of the disease. Therefore, the purpose of this review was to strengthen attention toward the use of metabolic modulators and to review the current level of knowledge on cardiac energy metabolic pathways.

Keywords: metabolic modulation, ischemic heart disease, cardiac energy metabolism, mitochondrial dynamics

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