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Targeted treatment of head and neck squamous-cell carcinoma: potential of lapatinib

Authors Gandhi M, Agulnik M

Received 13 November 2013

Accepted for publication 25 December 2013

Published 13 February 2014 Volume 2014:7 Pages 245—251


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 4

Mitul D Gandhi, Mark Agulnik

Division of Hematology and Oncology, Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA

Abstract: Squamous-cell cancer of the head and neck is a heterogeneous malignancy with treatment predicated on a multimodality therapy involving surgery, chemotherapy, and radiation. However, this approach results in durable responses in only a subset of patients, and is associated with significant toxicity. In advanced disease, multi-agent platinum-based chemotherapy produces only modest improvements in survival. Increased insight into tumor biology has demonstrated several critical oncogenic pathways offering prospects for targeted therapy that may improve upon the existing treatment strategies. The epidermal growth factor receptor is one such target, and directed therapy with the monoclonal antibody cetuximab has been extensively studied. Lapatinib is an oral agent that targets multiple transmembrane receptors within the epidermal growth factor receptor family, and offers a promising new approach to treatment. This paper reviews the rationale for and clinical activity of lapatinib in squamous-cell cancer of the head and neck.

Keywords: epidermal growth factor receptor, targeted therapy, oral cavity, pharynx, larynx

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