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Targeted treatment in COPD: a multi-system approach for a multi-system disease

Authors David Anderson, William MacNee

Published 31 August 2009 Volume 2009:4 Pages 321—335

DOI https://doi.org/10.2147/COPD.S2999

Review by Single-blind

Peer reviewer comments 4

David Anderson1, William MacNee2

1South Glasgow University NHS Trust, Glasgow, UK; 2University of Edinburgh, UK

Abstract: Chronic obstructive pulmonary disease is a varied condition when examined from a number of different perspectives including factors which influence disease development, pathological process and clinical features. There may be a complex interaction between the degree by which each of these processes influences the development of COPD and the subsequent clinical phenotype with which the patient presents. The varied host response and subsequent clinical phenotype has generated much interest in recent years. It is possible that failure of treatment to impact on mortality and reverse the disease process is because of the heterogeneous nature of the condition. Identification and targeted treatment of clinical and pathological phenotypes within the broad spectrum of COPD may therefore improve outcome. This article will review previous work which has attempted to phenotype COPD and identify if specific treatment for these phenotypes has been shown to be of benefit. It will examine the work on pathological processes and clinical manifestations, both pulmonary and systemic, and will focus on pharmacological therapies.

Keywords: COPD, clinical phenotypes, pathological phenotypes

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