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Targeted therapy and immunotherapy for platinum-refractory advanced ovarian adenosquamous carcinoma: a case report

Authors Li A, Sun S, Song T, Li X, Cheng W, Yao R, Zhang D, Cai Z, Zhang J, Zhai D, Yu C

Received 18 January 2018

Accepted for publication 25 April 2018

Published 27 June 2018 Volume 2018:11 Pages 3705—3711

DOI https://doi.org/10.2147/OTT.S162985

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Ms Justinn Cochran

Peer reviewer comments 3

Editor who approved publication: Dr Carlos E Vigil


Anji Li,1,2,* Shuai Sun,2,* Tao Song,3 Xi Li,2 Wen Cheng,2 Ruipin Yao,2 Danying Zhang,2 Zailong Cai,4 Jie Zhang,5 Dongxia Zhai,2 Chaoqin Yu2

1Shanghai University of Traditional Chinese Medicine, Shanghai 201203, People’s Republic of China; 2Department of Gynecology of Traditional Chinese Medicine, Changhai Hospital, Second Military Medical University, Shanghai 200433, People’s Republic of China; 3Department of Radiology, Changhai Hospital, Second Military Medical University, Shanghai 200433, People’s Republic of China; 4Department of Biochemistry and Molecular Biology, Second Military Medical University, Shanghai 200433, People’s Republic of China; 5Department of Assisted Reproduction, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, People’s Republic of China

*These authors contributed equally to this work

Background: Ovarian adenosquamous carcinoma is an extremely rare type of ovarian histology. Platinum-refractory disease is also uncommon, but can be fatal because of the lack of available treatment options. To date, there is no study or case report on platinum-refractory ovarian adenosquamous carcinoma or its relevant treatment.
Case presentation: Herein, we report the case of a 38-year-old Chinese woman with platinum-refractory advanced ovarian adenosquamous carcinoma who received clinical benefit from poly adenosine diphosphate ([ADP] ribose) polymerase and programmed death-1 inhibitors after failure of prior multiline chemotherapies and antiangiogenic agents. The targeted therapy and immunotherapy-controlled disease deterioration and improved performance status. Thus far, the patient has survived longer than 15 months, and she is taking nivolumab as maintenance treatment.
Conclusion: Targeted therapy and immunotherapy may be options for rare categories of ovarian cancer, but this warrants more clinical evidence of efficacy and toxicity.

Keywords: ovarian adenosquamous carcinoma, platinum-refractory, olaparib, nivolumab, pembrolizumab

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