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Targeted agents for the treatment of metastatic melanoma

Authors Monzon, Dancey J

Received 29 November 2011

Accepted for publication 15 January 2012

Published 5 March 2012 Volume 2012:5 Pages 31—46

DOI https://doi.org/10.2147/OTT.S21259

Review by Single anonymous peer review

Peer reviewer comments 3



Jose G Monzon, Janet Dancey

NCIC Clinical Trials Group, Kingston, Ontario, Canada

Abstract: In the last year, the armamentarium of melanoma therapeutics has radically changed. Recent discoveries in melanoma biology and immunology have led to novel therapeutics targeting known oncogenes and immunotherapeutic antibodies. Phase III clinical trials of these agents have reported measurable and meaningful benefits to patients with metastatic disease. In this article, we review recent findings and discuss their significance in melanoma therapy. As our understanding of melanoma biology grows, this initial therapeutic success may be enhanced through the use of molecular markers to select patients, and new targeted immunotherapies in sequential or combination drug regimens.

Keywords: metastatic melanoma, ipilimumab, vemurafenib, antitumor

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