Systemic abnormalities associated with retinal vein occlusion in young patients
Received 21 November 2016
Accepted for publication 25 January 2017
Published 23 February 2017 Volume 2017:11 Pages 441—447
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Colin Mak
Peer reviewer comments 2
Editor who approved publication: Dr Scott Fraser
Suthasinee Sinawat,1 Chavisa Bunyavee,2 Tanapat Ratanapakorn,1 Supat Sinawat,3 Wipada Laovirojjanakul,1 Yosanan Yospaiboon1
1KKU Eye Center, Department of Ophthalmology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand; 2Department of Ophthalmology, Faculty of Medicine, Nawamindaradhiraj University, Bangkok, Thailand; 3Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
Objectives: To study the systemic abnormalities associated with retinal vein occlusion in patients aged ≤50 years with a particular emphasis on atherosclerotic diseases and thrombophilic disorders.
Methods: Medical charts of patients, aged ≤50 years whose diagnoses were retinal vein occlusions during the period 1995–2015 were retrospectively reviewed. The primary outcome was the number of systemic abnormalities associated with these patients. Secondary outcomes included types of retinal vein occlusion and sites of occlusion.
Results: Atherosclerotic diseases were the most common systemic abnormalities associated with retinal vein occlusion and accounted for 55.1% of the patients in the study. Hypertension in 27.55%, diabetes mellitus in 16.33%, and 5.1% with dyslipidemia were noted. The number of thrombophilic disorders seemed to be less than expected and were noted in only 5.1%. Other systemic abnormalities included viral hepatitis infection, systemic lupus erythematosus, and acquired immunodeficiency syndrome. Oral contraceptives were used by some patients.
Conclusion: Atherosclerotic diseases remained the most commonly associated systemic diseases in the majority of these patients. Approach to these patients should include a screening for hypertension, diabetes mellitus, and lipid abnormalities. Thrombophilia should also be considered where no obvious atherosclerotic diseases are found or if the patient is <40 years old, a history of thrombosis or a family history of thrombosis is possible.
Keywords: retinal vein occlusion, systemic diseases, young patients
This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.Download Article [PDF] View Full Text [HTML][Machine readable]
Other articles by this author:
Thanathanee O, Bhoomibunchoo C, Anutarapongpan O, Suwan-apichon O, Yospaiboon Y
Published Date: 20 March 2017
Idiopathic polypoidal choroidal vasculopathy in Thai patients with clinical and angiographic choroidal neovascularization
Bhoomibunchoo C, Yospaiboon Y, Thoongsuwan S, Rojanaporn D, Watanachai N, Jirarattanasopa P, Wongcumchang N, Amphornphruet A, Vongkulsiri S, Arayangkoon E
Published Date: 9 February 2017
Incidence of and risk factors for chloroquine and hydroxychloroquine retinopathy in Thai rheumatologic patients
Tangtavorn N, Yospaiboon Y, Ratanapakorn T, Sinawat S, Sanguansak T, Bhoomibunchoo C, Laovirojjanakul W
Published Date: 2 November 2016
Macular sensitivity after half-dose verteporfin photodynamic therapy in central serous chorioretinopathy
Sanguansak T, Pitujaturont P, Yospaiboon Y, Sinawat S, Ratanapakorn T, Bhoomibunchoo C
Published Date: 1 December 2015
Bhoomibunchoo C, Ratanapakorn T, Sinawat S, Sanguansak T, Moontawee K, Yospaiboon Y
Published Date: 1 February 2013
Thanathanee O, Ratanapakorn T, Morley MG, Yospaiboon Y
Published Date: 15 February 2012