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Synthesis of gold nanoparticles with Solanum xanthocarpum extract and their in vitro anticancer potential on nasopharyngeal carcinoma cells

Authors Zhang P, Wang P, Yan L, Liu L

Received 13 July 2018

Accepted for publication 3 August 2018

Published 1 November 2018 Volume 2018:13 Pages 7047—7059

DOI https://doi.org/10.2147/IJN.S180138

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Govarthanan Muthusamy

Peer reviewer comments 2

Editor who approved publication: Dr Linlin Sun


Pengfei Zhang,1,* Peicheng Wang,2,* Lei Yan,3 Lifeng Liu1

1Department of Otolaryngology – Head and Neck Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi 710061, China; 2Department of Otolaryngology – Head and Neck Surgery, Weihai Municipal Hospital, Weihai, Shandong 264200, China; 3Innoscience Research Sdn. Bhd, Subang Jaya, Selangor 47500, Malaysia

*These authors contributed equally to this work

Background: Nasopharyngeal cancer (NPC) is one of the subtypes of head and neck cancers. It occurs rarely, and its prevalence depends mainly on geographical location. Modern-day research is focused on coupling nanotechnology and traditional medicine for combating cancers. Gold nanoparticles (AuNPs) were synthesized from Solanum xanthocarpum (Sx) leaf extract using reduction method.
Methods: Characterization of the synthesized AuNPs was done by different techniques such as ultraviolet–visible spectrum absorption, X-ray diffraction, dynamic light scattering, Fourier transform infrared spectroscopy, transmission electron microscopy, and energy-dispersive X-ray analysis.
Results: All the results showed the successful green synthesis of AuNPs from Sx, which induced apoptosis of C666-1 cell line (NPC cell line). There was a decline in both cell viability and colony formation in C666-1 cells upon treatment with Sx-AuNPs. The cell death was proved to be caused by autophagy and mitochondrial-dependent apoptotic pathway.
Conclusion: Thus, due to their anticancer potential, these nanoparticles coupled with Sx can be used for in vivo applications and clinical research in future.

Keywords: Solanum xanthocarpum, gold nanoparticle, C666-1 cells, ROS, apoptosis

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