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Synthesis and characterization of multifunctional gold nanoclusters for application in radiation therapy

Authors Baronia R, Singh M, Gupta RB, Karuppiah S, Kumar R, Belz J, Shanker R, Sridhar S, Singh SP

Received 18 October 2016

Accepted for publication 4 March 2017

Published 15 March 2018 Volume 2018:13(T-NANO 2014 Abstracts) Pages 113—115

DOI https://doi.org/10.2147/IJN.S125006

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Lei Yang


Richa Baronia,1 Manjri Singh,1 Rajat B Gupta,1 Stalin Karuppiah,1 Rajiv Kumar,2 Jodi Belz,2 Rishi Shanker,3 Srinivas Sridhar,2 Surinder P Singh1

1CSIR-National Physical Laboratory, Dr KS Krishnan Marg, New Delhi, India; 2Nanomedicine Science and Technology Center, Northeastern University, Boston, MA, USA; 3Institute of Life Sciences, Ahmedabad University, Ahmedabad, India


Abstract: Gold nanoparticles, because of their high radiation absorption coefficient and efficient generation of secondary photoelectrons, have been predicted to enhance therapeutic efficacy in radiation therapy. However, high dose for effective treatment limits their use. We have synthesized multifunctional gold nanoclusters (GNCs) that can be used for imaging and radiation therapy. The designed GNCs have been characterized for their physicochemical properties, biocompatibility, and their radiation dose enhancement potential on PC3 cell lines.

Keywords: gold nanoclusters, radiation therapy

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