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Synergism between PGC-1α and estrogen in the survival of endometrial cancer cells via the mitochondrial pathway

Authors Yang H, Yang R, Liu H, Ren Z, Kong F, Li D, Ma X

Received 1 January 2016

Accepted for publication 9 March 2016

Published 30 June 2016 Volume 2016:9 Pages 3963—3973

DOI https://doi.org/10.2147/OTT.S103482

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Lucy Goodman

Peer reviewer comments 3

Editor who approved publication: Dr William Cho


Hui Yang, Rui Yang, Hao Liu, Zhongqian Ren, Fanfei Kong, Da Li, Xiaoxin Ma

Department of Obstetrics and Gynecology, Shengjing Hospital Affiliated to China Medical University, Shenyang, Liaoning, People’s Republic of China

Abstract: Accumulating evidence shows that peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α) is involved in the progression of hormone-related cancers, and there may exist an association between estrogen and PGC-1α. Notably, emerging evidence has led to considerable interest in the role of PGC-1α in endometrial cancer development. However, whether the synergism exists between PGC-1α and estrogen for regulating mitochondrial function to promote the development of endometrial cancer remains largely unknown. Here, we show that: 1) knockdown of PGC-1α attenuates the survival of endometrial cancer cells by inducing cell apoptosis through the mitochondrial pathway; 2) estrogen remedies the PGC-1α efficiency-induced decline of endometrial cancer cell viability; and 3) estrogen modulates the mitochondrial function to inhibit the PGC-1α deficiency-induced apoptosis in endometrial cancer cells. Collectively, these results demonstrated that the synergism between PGC-1α and estrogen was required for the survival of endometrial cancer cells, which was dependent on the mitochondrial pathway.

Keywords:
PGC-1α, estrogen, endometrial cancer, survival, mitochondrial pathway

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