Back to Journals » International Journal of Nanomedicine » Volume 11

Symbiosis theory-directed green synthesis of silver nanoparticles and their application in infected wound healing

Authors Wen L, Zeng P, Zhang L, Huang W, Wang H, Chen G

Received 18 February 2016

Accepted for publication 13 April 2016

Published 10 June 2016 Volume 2016:11 Pages 2757—2767

DOI https://doi.org/10.2147/IJN.S106662

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Dr Lei Yang


Lu Wen,1 Pei Zeng,1 Liping Zhang,1 Wenli Huang,1 Hui Wang,2 Gang Chen1

1Department of Pharmaceutics, School of Pharmacy, 2School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China

Abstract: In this study, silver nanoparticles (AgNPs) were synthesized for the first time using an antibacterial endophytic fungus of Chinese medicinal herb Orchidantha chinensis, which has anti-inflammatory and antimicrobial activities. The AgNPs were analyzed by various characterization techniques to reveal their morphology, chemical composition, and stability. Also, the relationship between Chinese medicinal herbs, endophytic fungi, and the property of AgNPs was investigated for the first time. Interestingly, an experiment performed in this study revealed the proteins produced by the endophytic fungus to be capped on the nanoparticles, which led to an increase in the stability of spherical and polydispersed AgNPs with low aggregation for over 6 months. More importantly, further study demonstrated that the AgNPs possessed superior antibacterial activity and effectively promoted wound healing. Altogether, the biosynthesis of active AgNPs using the endophytic fungus from Chinese medicinal herb based on the symbiosis theory is simple, eco-friendly, and promising.

Keywords: silver nanoparticles, Orchidantha chinensis, endophytic fungi, symbiosis theory, wound healing

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]