Back to Journals » Clinical Interventions in Aging » Volume 9

Sustained effect of resistance training on blood pressure and hand grip strength following a detraining period in elderly hypertensive women: a pilot study

Authors da Cunha Nascimento D, Alsamir Tibana R, Benik F, Fontana KE, Ribeiro Neto F, Santos de Santana F, Santos-Neto L, André Sousa Silva R, Silva A, Lopes Farias D, Balsamo S, Prestes J

Received 16 October 2013

Accepted for publication 9 November 2013

Published 20 January 2014 Volume 2014:9 Pages 219—225


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Download Article [PDF] 

Dahan da Cunha Nascimento,1,5,8 Ramires Alsamir Tibana,1,8 Franklin M Benik,2 Keila Elizabeth Fontana,3 Frederico Ribeiro Neto,8 Frederico Santos de Santana,5,8 Leopoldo Santos-Neto,4 Renato André Sousa Silva,1,5,6 Alessandro Oliveira Silva,1,7 Darlan Lopes Farias,1,7 Sandor Balsamo,4,5,8 Jonato Prestes1

1Postgraduate Program in Physical Education, Catholic University of Brasilia, Brasilia, Brazil; 2Department of Kinesiology and Sports Studies Graduate Program, Eastern Illinois University, Charleston, IL, USA; 3Faculty of Physical Education, University of Brasilia, Brasilia, Brazil; 4Graduate Program in Medical Sciences of the University of Brasilia, School of Medicine and Rheumatology Service, University Hospital of Brasilia (HUB), Brasilia, Brazil; 5Department of Physical Education, University Center Euro American University Center, Brasilia, Brazil; 6Center of Excellence in Medicine of Exercise (CEMEx), Brasilia, Brazil; 7Center University of Brasilia (UNICEUB), Brasilia, Brazil; 8Strength Training and Health Research Group (GEPEEFS), Brasilia, Brazil

Introduction: Hypertension is the most prevalent modifiable risk factor with a high prevalence among older adults. Exercise is a nonpharmacological treatment shown to benefit all patients with hypertension.
Objective: This study examined the effects of a 14-week moderate intensity resistance training program (RT) on the maintenance of blood pressure and hand grip strength during an extended detraining period in elderly hypertensive women.
Methods: Twelve hypertensive sedentary elderly women completed 14 weeks of whole body RT at a moderate perceived exertion following a detraining period of 14 weeks.
Results: Following the training period, participants demonstrated an increase in absolute hand grip strength (P=0.001), relative hand grip strength (P=0.032) and a decrease of systolic (P=0.001), diastolic (P=0.008), and mean blood pressure (P=0.002) when compared to pre-exercise values. In addition, these effects were sustained after 14 weeks of detraining.
Conclusion: Resistance training may be a valuable method to improve muscular strength and blood pressure in elderly people with benefits being maintained up to 14 weeks following training cessation.

Keywords: aging, resistance training, hypertension, detraining, elderly


Hypertension is the most prevalent modifiable risk factor for cardiovascular morbidity and mortality worldwide, with a high prevalence among older adults (≥65 years).1 Some factors like endothelial dysfunction and increased arterial stiffness contribute to the increased prevalence of hypertension among the elderly, particularly systolic hypertension, while alarming data revealed a 68% prevalence of hypertension in elderly persons from Brazil.2

Nonpharmacological treatment, including exercise, has been shown to benefit all patients with hypertension, including elderly women. It has been suggested that resistance training (RT) can be a nonpharmacological intervention to prevent and treat high blood pressure.3 This method of training has positive effects on functional capabilities and limitations of the elderly by increasing muscular strength, cardiovascular function, decreasing coronary artery disease (CAD), and preventing hypertension.47 Moreover, studies have shown that there is a correlation between low muscular strength and degenerative conditions, such as sarcopenia, cognitive decline, cancer, CAD, disability, and eventually mortality.813

For individuals who exercise, regardless of age, it is reasonable to assume that at some point, periods of training cessation or inactivity will occur. Among all age groups, older individuals have a higher propensity for training disruptions due to planned or unplanned factors, ranging from illness to vacations.14

It has been shown that muscular strength in older subjects can be maintained above baseline levels for 12–48 weeks of detraining following an RT program, while systolic (SBP) and diastolic blood pressure (DBP) can be maintained below baseline levels following four weeks of detraining in hypertensive middle-aged men.15,16 Although there is evidence that the sustained effect of exercise on strength can be maintained for an extended period after training cessation, to the best of our knowledge, only one preview study verified the effect of training cessation on blood pressure. Additionally, no studies to date have examined the chronic effects of RT on blood pressure (BP) and muscular strength following a detraining period in elderly sedentary hypertensive women.1417

Therefore, the aim of the present study was to investigate what effect a 14-week moderate intensity RT program would have on BP and muscular strength during an extended detraining period in elderly hypertensive sedentary women. The initial hypothesis was that BP and muscular strength would improve in response to RT and these beneficial effects would be sustained during the detraining period.

Materials and methods


The sample of this study consisted of 12 elderly women (67.6±6.4 years; height, 1.51±0.05 m; weight, 62.75±11.78 kg; and body mass index, 27.49±5.81 kg/m²) from the local community. As stated by the Brazilian Ministry of Health under ordinance 1395/GM 1999, an older person is considered to be anyone aged 60 years or older. Additionally, all participants had to be sedentary, ie, someone who had not been engaged in regular exercise programs for at least six months prior to the study (<2 hours/week) and hypertensive stage 1.18 All subjects were recruited through advertisements placed in the local community. According to the criteria set by the American College of Sports Medicine, the participants were considered “untrained.”19

The exclusion criteria were: women younger than 60 years, undiagnosed hypertension, SBP greater than or equal to 160 or DBP greater than or equal to 100 mmHg, smoking history, cardiac arrhythmia, arterial coronary disease, history of acute myocardial infarction, stroke, congestive heart disease, and physical disabilities. The selection of the participants is presented in Figure 1.

Figure 1 Scheme of the selection of the volunteers.
Abbreviation: RT, resistance training.

The study was conducted at the strength training laboratory of the Euro American University Center (UNIEURO), from June 2011 to February 2012. According to the research involving humans of Resolution 196/96 on the National Health Council and declaration of Helsinki,20,21 all subjects were informed of the procedures and provided with a written informed consent to participate in the study. All methods and procedures were approved by the Research Ethics Committee of the UNIEURO (Protocol number 154/2011).

BP measurement

The procedures for BP measurement both before and after training, as well as during detraining were based on the guidelines set forth by the VII Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure, which recommends a seated position with uncrossed legs, feet flat on the floor, and left arm supported at heart level.18 Additionally, BP was measured with a calibrated automated oscillometric noninvasive validated BP device (model Microlife BP 3BTO-A, Onbo Electronic, Shenzhen, Co., Ltd).22 The values of SBP and DBP were used to calculate the mean blood pressure (MBP) utilizing the formula: MBP = DBP + (SBP - DBP)/3. All BP (SBP and DBP) measures were assessed in triplicate (measurements separated by 1 minute) with the mean value used for analysis.

The elderly women were instructed beforehand not to carry out any kind of vigorous physical activity or ingest alcoholic and caffeinated beverages for 24 hours prior to the measurement days. All measurements of BP and grip strength were performed by the same researcher at the same time of day (between 2 pm and 4.30 pm) under controlled room temperature.

Hand grip strength (HGS) measurement

Isometric HGS was determined by the use of a hand grip dynamometer (TKK, GRIP D; Takei Scientific Instruments Co, Niijata, Japan) used in previous studies.8,23 The three measures on the right and left hand were averaged to get the absolute HGS. The hand position and nail length were adjusted individually and a 1 minute rest period between measurements was adopted.24 To calculate the relative HGS (HGS/kg), the HGS was divided by the individual’s body weight in kilograms.25

Resistance training program

Subjects completed 2 weeks of familiarization prior to the RT program and were advised regarding the execution of proper technique and use of rating of perceived exertion (RPE). Sessions were completed twice each week with each exercise consisting of a single set of 15 repetitions.

The RT program was conducted two times per week over 14 weeks, consisting of three sets with a training zone of eight to twelve repetitions, at a moderate intensity, using a modified version of perceived exertion (1–10 point scale).2628 Although tolerance to the higher loads was observed, the same intensity (according to RPE) was used during the 14 weeks of resistance training. The training sessions were conducted during the same time of day (between 2 pm and 4.30 pm). Each training session began with 15 minutes of stretching with an emphasis on the ankle, hip, and lumbar joints followed by a warm up of 5 minutes on a treadmill walking with a standard speed of 4.0 to 5.0 km/h.29 The exercises were performed on fitness machines (Johnson Health Technologies Inc, Taiwan) in the following order: seated bench press, rotary cuff, leg extension, leg curl, leg press, and front lat-pull down. The rest interval between sets and exercises was 2 minutes. The participants were instructed to avoid the Valsalva maneuver during exercises. The ratio of supervision was one instructor to every five participants (1:5).

Diet and physical activity control

No dietary advice was provided, and during the training and detraining period, participants were allowed to maintain any recreational activities they were currently involved in, but were discouraged from participating in any new activities or regular exercise training. Following 14 weeks of detraining, the subjects were reassessed with identical procedures at similar times of the day as the training phase.

Statistical analysis

The statistical analysis was initially done by the Shapiro–Wilk normality test and by the homoscedasticity test (Mauchly test). All variables presented normal distribution and homocedasticity. A repeated measures analysis of variance was used, and when the differences presented significance, the Bonferroni post hoc test was applied.30 The intention to treat analysis was completed to account for missing data due to participant withdrawal.31 The differences in the percent changes from pre-training to post-training and from pre-training to detraining were analyzed by the formula: (initial score – final score)/initial score ×100. To calculate the effect size, the eta (n²) demonstrated by Statistical Package for Social Sciences (SPSS, Inc., v. 18.0; IBM Corporation, Armonk, NY, USA) was utilized. For determination of the magnitude of effect sizes the following values were used. Small (0.20–0.49), moderate (0.5–0.79), and large (0.8).32 Considering a power of 80%, an alpha error of 0.05, number of groups (n=1), measurements, and a direct partial n² of 0.65 demonstrated in this study, the sample size necessary to detect differences of 5 mmHg within moments during the entire study period for the main variable SBP was calculated to be seven individuals.

An alpha level of P≤0.05 was considered statistically significant for all comparisons. The software SPSS (Inc., v. 18.0, IBM Corporation) and G*Power 3.1.633 was used for all statistical analysis and power calculations.


A total of 15 participants agreed to participate, with twelve completing the 14-week RT program. Three participants were excluded and only one unspecified absence (personal reasons) occurred among the remaining twelve participants during the 14-week RT program. During the detraining period, nine participants completed the evaluations and three participants could not due to eye surgery (n=2) or vacation (n=1). All subjects who participated in the RT sessions did not exhibit any problems or adverse events associated with the intervention. The listing of the participants’ medications is shown in Table 1. In addition, no medications changed during the study.

Table 1 Frequency and percentage of the medications consumed by the participants

After 14 weeks of RT and 14 weeks of detraining, SBP (P=0.001, P=0.008, F[2.16] =15; P=0.001, effect size [ES] =0.65) and MBP (P=0.002, P=0.012, F[2.16] =11; P=0.001, ES =0.46) decreased significantly when compared with pre-training (Table 2 and Figure 2). DBP decreased after the training period when compared with pre-training (P=0.008, F[2.16] =7; P=0.007), although there was no significant difference in DBP during the detraining period (P=0.058, ES =0.46); it remained 13% lower when compared to pre-training values (Table 2 and Figure 2).

Table 2 Hemodynamic parameters at pre-training, post-training and detraining
Notes: Data are reported with mean and standard deviation. *P<0.05 from pre-training.
Abbreviations: CI, confidence interval; DBP, diastolic blood pressure; SBP, systolic blood pressure; HGS, absolute hand grip strength; HGS/kg, relative hand grip strength during 14-week training followed by 14-week detraining; MBP, mean blood pressure; n2, eta squared.

Figure 2 Blood pressure changes in elderly sedentary hypertensive women.
Notes: (A) Systolic blood pressure, (B) diastolic blood pressure, and (C) mean blood pressure during 14 weeks of resistance training followed by 14 weeks of detraining. Data are presented as mean ± standard deviation. *denotes P<0.05 versus pre-training.

Following the 14 weeks of RT, relative HGS increased when compared with pre-training measures (P=0.032, F[2.16] =5; P=0.016), although there was no difference in relative HGS after the detraining (P=0.34, ES =0.59). It remained 6% higher when compared with pre-training values (Table 2 and Figure 3). The absolute HGS was higher in the post-training and detraining periods when compared with pre-training values (P=0.005 and 0.017, F[2.16] =13; P=0.001, ES =0.75) (Table 2).

Figure 3 Hand grip strength changes in older sedentary hypertensive women.
Notes: (A) Absolute hand grip strength and (B) relative hand grip strength during 14 weeks of resistance training followed by 14 weeks of detraining. Data are presented as mean ± standard deviation. *denotes P<0.05 versus pre-training.


The aim of the present study was to investigate the effect of a 14-week moderate intensity RT program on the maintenance of BP and HGS during an extended detraining period in older hypertensive sedentary women. Confirming the initial hypothesis, after 14 weeks of detraining, SBP and MBP remained statistically significant compared to pre-training values, while the absolute HGS remained statistically significant compared to the pre-training values. Besides, the clinical significance demonstrated by the effect size remained above 0.5 for the SBP, MBP, HGS, and HGS/kg. Only for DBP was the effect small.

Although the ES is a measure of importance, it may not be clinically relevant.34 We previously commented that an ES above 0.5 was observed for SBP among other variables, while a small ES was found for DBP. Despite the low magnitude of DBP effect sizes during the detraining period when compared to post-training, a small reduction of 2 mmHg in the DBP and SBP could help prevent CAD and stroke events.35,36

To the best of our knowledge, no previous study has evaluated the effect of RT followed by a detraining period on BP and HGS in elderly hypertensive sedentary women. The results of the present study revealed that even after a 14-week detraining period following RT, hypertensive older women were able to maintain the benefits on BP and muscular strength. Recently, Moraes et al15 found a decrease of 16 mmHg in SBP of hypertensive middle-aged men after 12 weeks of RT. Moreover, the benefits of BP reduction achieved with RT training were sustained for up to 4 weeks without exercise. However, in contrast to the present study, the population was middle-aged men (46±3 years), with a shorter detraining period of 4 weeks and participants had all antihypertensive medications gradually withdrawn. The study by Moraes et al15 is the only one that evaluated the effects of detraining (4 weeks) on BP in hypertensive individuals. Despite the clinical effect found (decreased BP sustained), the effects of RT cessation on BP without a washout period (medication withdraw) in elderly hypertensive women were poorly understood.

The potential mechanisms underlying the reduction and maintenance of BP following the detraining period have been previously studied. Some proposals indicate that reduction in peripheral vascular resistance by a decline in cardiac output, a release of vasoactive factors, an increase in baroreflex sensibility, and greater participation in physical activities unrelated to RT might be involved.16

For muscular strength, although measured by hand grip, our results are in accordance with previous results that show elderly individuals display decreased neuromuscular performance after a period of detraining, but retain higher values than pre-training levels. Correa et al37 performed a similar longitudinal protocol using elderly women that consisted of twelve weeks of an RT program twice a week followed by twelve weeks of detraining. The results of this study found that strength gains were partially maintained following the detraining period. Lovell et al38 found similar results in older men following four weeks of detraining. Furthermore, previous studies have shown that the muscular strength of elderly individuals, when subjected to RT of moderate to high intensity, can be maintained above baseline levels during 12 to 48 weeks of detraining.16,17 Although, similar results were found for muscular strength, it is difficult to compare the data collected in this study with other studies because tests that involve one or more maximum repetitions were not utilized and the intensity control during the training period was made by participant self-report using an RPE scale, which results in higher intersubject variability.

The accurate measurement of muscle strength requires expensive equipment, and the results have low applicability when compared to simple measures of muscle strength utilizing HGS. HGS is strongly associated with muscle power and force of the lower limbs in older persons, and is relatively practical, reproducible, and inexpensive.13 In addition, HGS is considered an important predictor of functional capacity, cardiovascular disease, cancer, mortality, dementia, and nutritional state in elderly people.8,11,39

The present study has some limitations. According to Lauretani et al,13 HGS is appropriate to monitor the effectiveness of systemic treatments, both pharmacological and nonpharmacological, aimed to improve muscular strength. However, exercise interventions may have a more variable impact on different muscle groups and should be monitored with appropriate regional measures. Additionally, our analysis was made in the absence of a control group, so flaws in the causal relationships should be considered. Moreover, salt intake and hydration status were not controlled, although participants were advised to maintain their normal dietary habits during the study. During the training period, the intensity of RT was individually controlled by the participants utilizing an RPE scale. This strategy may not have normalized the relative effort in the group, because each participant has a different interpretation of their exertion level. Furthermore, the presence of heterogeneity in medications used by our subjects might have introduced bias in our hemodynamic results.

Despite the limitations, our findings raise interesting ideas for future research trials, such as the investigation of periodization, volume, intensity, and training frequency which may contribute to the maintenance and control of muscular strength and BP during short and long-term detraining periods.


This study highlighted that RT of moderate intensity controlled by RPE improved BP and HGS, and was sufficient to maintain these benefits for 14 weeks of detraining in older hypertensive women. These results present important clinical application, considering that this sustained decrease in BP and increased strength can protect older individuals from several degenerative processes associated with aging.


The authors would like to thank those individuals who assisted in supervising the training and especially the subjects who volunteered and participated. In addition, the first author wants to dedicate this paper to his family (Rita de Cassia, Luana Cunha, Nicolas Cunha and Dejanira Cunha).


The authors declare no conflict of interest. The authors alone are responsible for the content and writing of the manuscript.



Pimenta E, Oparil S. Management of hypertension in the elderly. Nat Rev Cardiol. 2012;9(5):286–296.


Picon RV, Fuchs FD, Moreira LB, Riegel G, Fuchs SC. Trends in prevalence of hypertension in Brazil: a systematic review with meta-analysis. PLoS One. 2012;7(10):e48255.


Cornelissen VA, Fagard RH. Effect of resistance training on resting blood pressure: a meta-analysis of randomized controlled trials. J Hypertens. 2005;23(2):251–259.


Latham NK, Bennett DA, Stretton CM, Anderson CS. Systematic review of progressive resistance strength training in older adults. J Gerontol A Biol Sci Med Sci. 2004;59(1):48–61.


Rantanen T, Guralnik JM, Foley D, et al. Midlife hand grip strength as a predictor of old age disability. JAMA. 1999;281(6):558–560.


Cornelissen VA, Fagard RH, Coeckelberghs E, Vanhees L. Impact of resistance training on blood pressure and other cardiovascular risk factors: a meta-analysis of randomized, controlled trials. Hypertension. 2011;58(5):950–958.


Pollock ML, Franklin BA, Balady GJ, et al. AHA Science Advisory. Resistance exercise in individuals with and without cardiovascular disease: benefits, rationale, safety, and prescription: An advisory from the Committee on Exercise, Rehabilitation, and Prevention, Council on Clinical Cardiology, American Heart Association; Position paper endorsed by the American College of Sports Medicine. Circulation. 2000;101(7):828–833.


Shin HY, Kim SW, Kim JM, Shin IS, Yoon JS. Association of grip strength with dementia in a Korean older population. Int J Geriatr Psychiatry. 2012;27(5):500–505.


Taekema DG, Gussekloo J, Maier AB, Westendorp RG, de Craen AJ. Handgrip strength as a predictor of functional, psychological and social health. A prospective population-based study among the oldest old. Age Ageing. 2010;39(3):331–337.


Cruz-Jentoft AJ, Baeyens JP, Bauer JM, et al; European Working Group on Sarcopenia in Older People. Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People. Age Ageing. 2010;39(4):412–423.


Gale CR, Martyn CN, Cooper C, Sayer AA. Grip strength, body composition, and mortality. Int J Epidemiol. 2007;36(1):228–235.


Artero EG, Lee DC, Ruiz JR, et al. A prospective study of muscular strength and all-cause mortality in men with hypertension. J Am Coll Cardiol. 2011;57(18):1831–1837.


Lauretani F, Russo CR, Bandinelli S, et al. Age-associated changes in skeletal muscles and their effect on mobility: an operational diagnosis of sarcopenia. J Appl Physiol. 2003;95(5):1851–1860.


Harris C, DeBeliso M, Adams KJ, Irmischer BS, Spitzer Gibson TA. Detraining in the older adult: effects of prior training intensity on strength retention. J Strength Cond Res. 2007;21(3):813–818.


Moraes MR, Bacurau RF, Casarini DE, et al. Chronic conventional resistance exercise reduces blood pressure in stage 1 hypertensive men. J Strength Cond Res. 2012;26(4):1122–1129.


Tokmakidis SP, Kalapotharakos VI, Smilios I, Parlavantzas A. Effects of detraining on muscle strength and mass after high or moderate intensity of resistance training in older adults. Clin Physiol Funct Imaging. 2009;29(4):316–319.


Fatouros IG, Kambas A, Katrabasas I, et al. Strength training and detraining effects on muscular strength, anaerobic power, and mobility of inactive older men are intensity dependent. Br J Sports Med. 2005;39(10):776–780.


Chobanian AV, Bakris GL, Black HR, et al; Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure, National Heart, Lung, and Blood Institute; National High Blood Pressure Education Program Coordinating Committee. Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension. 2003;42(6):1206–1252.


McGuigan MR, Kraemer WJ, Deschenes MR, et al. Statistical analysis of fiber area in human skeletal muscle. Can J Appl Physiol. 2002;27(4):415–422.


World Medical Association (WMA). World Medical Association Declaration of Helsinki: Ethical Principles for Medical Research Involving Human Subjects. Ferney-Voltaire: WMA; 2008. Available from: Accessed December 12, 2013.


Ministério da Saúde. Conselho Nacional de Saúde (CNS). Comissão Nacional de ética em Pesquisa: 2012. Available from: Accessed December 12, 2013.


Cuckson AC, Reinders A, Shabeeh H, Shennan AH. Validation of the Microlife BP 3BTO-A oscillometric blood pressure monitoring device according to a modified British Hypertension Society protocol. Blood Press Monit. 2002;7(6):319–324.


Tibana RA, Balsamo S, Prestes J. Association between muscle strength and at-rest blood pressure among sedentary women. Rev Bras Cardiol. 2011;24(3):163–168.


Tibana RA, Teixeira TG, Farias DL, et al. Relation of neck circumference and relative muscle strength and cardiovascular risk factors in sedentary women. Einstein (Sao Paulo). 2012;10(3):329–334.


Prestes J, Tibana RA. Muscular static strength test performance and health: absolute or relative values? Rev Assoc Med Bras. 2013;59(4):308–309.


Nelson ME, Rejeski WJ, Blair SN, et al; American College of Sports Medicine; American Heart Association. Physical activity and public health in older adults: recommendation from the American College of Sports Medicine and the American Heart Association. Circulation. 2007;116(9):1094–1105.


Borg G. Borg’s Perceived Exertion and Pain Scales. Champaign (IL): Human Kinetics; 1998.


Gladwell VF, Sandercock GR, Birch SL. Cardiac vagal activity following three intensities of exercise in humans. Clin Physiol Funct I. 2010;30(1):17–22.


American College of Sports Medicine, Chodzko-Zajko WJ, Proctor DN, et al. American College of Sports Medicine position stand. Exercise and physical activity for older adults. Med Sci Sports Exerc. 2009;41(7):1510–1530.


Field, A. P. Discovering statistics with SPSS. 2nd ed. London: Sage; 2005.


Streiner D, Geddes J. Intention to treat analysis in clinical trials when there are missing data. Evid Based Ment Health. 2001;4(3):70–71.


Cohen J. Statistical Power Analysis for the Behavioral Sciences. 2nd ed. Routledge: Lawrence Erlbaum Associates; 1988.


Faul F, Erdfelder E, Lang A, Buchner A. G*Power 3: A flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behavior Research Methods. 2007;(39)2:175–191.


Kalinowski P, Fidler F. Interpreting significance: the differences between statistical significance, effect size, and practical importance. Newborn and Infant Nursing Reviews. 2010;10(1):50–54.


Cook NR, Cohen J, Hebert PR, Taylor JO, Hennekens CH. Implications of small reductions in diastolic blood pressure for primary prevention. Arch Intern Med. 1995;155(7):701–709.


Lawes CM, Bennett DA, Feigin VL, Rodgers A. Blood pressure and stroke: an overview of published reviews. Stroke. 2004;35(4):1024.


Correa CS, Baroni BM, Radaelli R, et al. Effects of strength training and detraining on knee extensor strength, muscle volume and muscle quality in elderly women. Age (Dordr). 2013;35(5):1899–1904.


Lovell DI, Cuneo R, Gass GC. The effect of strength training and short-term detraining on maximum force and the rate of force development of older men. Eur J Appl Physiol. 2010;109(3):429–435.


Rantanen T, Volpato S, Ferrucci L, Heikkinen E, Fried LP, Guralnik JM. Handgrip strength and cause-specific and total mortality in older disabled women: exploring the mechanism. J Am Geriatr Soc. 2003;51(5):636–641.

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]