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Susceptibility of PON1/PON2 Genetic Variations to Ischemic Stroke Risk in a Chinese Han Population

Authors Pan Y, He B, Sun H, Xu T, Pan B, Wang S, Mei Y

Received 3 August 2020

Accepted for publication 6 October 2020

Published 29 October 2020 Volume 2020:13 Pages 563—570

DOI https://doi.org/10.2147/PGPM.S275341

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Martin Bluth


Yuqin Pan,1,* Bangshun He,1,* Huiling Sun,1 Tao Xu,1 Bei Pan,1 Shukui Wang,1 Yanping Mei2

1General Clinical Research Center, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu Province, 210006, People’s Republic of China; 2Department of Laboratory Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, People’s Republic of China

*These authors contributed equally to this work

Correspondence: Shukui Wang
General Clinical Research Center, Nanjing First Hospital, Nanjing Medical University, 68 Changle Road, Nanjing, Jiangsu 210006, People’s Republic of China
Email shukwang@163.com
Yanping Mei
Department of Laboratory Medicine, Nanjing First Hospital, Nanjing Medical University, 68 Changle Road, Nanjing, Jiangsu 210006, People’s Republic of China
Email 4940556@qq.com

Background: Paraoxonases (PONs) are a family of orphan enzymes with multiple functions, including anti-inflammatory, antioxidative, antiatherogenic activities. Studies have suggested that genetic variations in PON1 and PON2 are associated with ischemic stroke (IS) risk; however, the conclusion remains unclear in the Chinese population.
Methods: To investigate the susceptibility of genetic variations in PON1 and PON2 to risk of IS and its subtypes, this case–control study was carried out on a Chinese population comprising 300 IS patients and 300 healthy controls. Genotypes of six genetic variations in PON1 and PON2 were identified with an improved multiplex ligase detection–reaction technique.
Results: PON1 rs662 was associated with increased risk of IS (CT vs. TT — ORadjusted 1.79, 95% CI 1.08– 2.97; p=0.025). Stratified analysis for patients by sex revealed that the significant association of PON1 rs662 with IS risk was maintained in the male cohort (CT vs. TT — ORadjusted 2.59, 95% CI 1.29– 5.21 [p=0.009]; CT/CC vs. TT — ORadjusted 2.03, 95% CI 1.05– 3.93 [p=0.036]), but not in the female cohort. Analysis according to IS subtype revealed that PON1 rs662 genetic variation was an increased risk in the subcohort of patients with large-artery atherosclerosis (CT/CC vs. TT — ORadjusted 2.31, 95% CI 1.09– 4.91; p=0.029), but not in patients with other types of IS.
Conclusion: This study suggested that PON1 rs662 presented a potential risk of IS, especially for males, and this association was more obvious for large-artery atherosclerosis.

Keywords: ischemic stroke, genetic variation, PON1, PON2

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