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Survival of Stroke Patients According to Hypertension Status in Northern Ethiopia: Seven Years Retrospective Cohort Study

Authors Hagos Gufue Z , Gizaw NF, Ayele W, Yifru YM, Hailu NA, Welesemayat ET, Tsegay EW , Atsbaha AH , Gebru HT 

Received 29 January 2020

Accepted for publication 15 September 2020

Published 30 September 2020 Volume 2020:16 Pages 389—401

DOI https://doi.org/10.2147/VHRM.S247667

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Konstantinos Tziomalos



Zenawi Hagos Gufue,1 Naod Firdu Gizaw,2 Wondimu Ayele,2 Yared Mamushet Yifru,3 Nigus Alemu Hailu,4 Embaba Tekelaye Welesemayat,5 Etsay Weldekidan Tsegay,6 Abadi Hailay Atsbaha,1 Hirut Teame Gebru1

1Department of Public Health, College of Medicine and Health Sciences, Adigrat University, Adigrat, Ethiopia; 2Department of Preventive Medicine, School of Public Health, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia; 3Department of Neurology, Faculty of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia; 4Department of Biomedical Sciences, School of Medicine, College of Medicine and Health Sciences, Adigrat University, Adigrat, Ethiopia; 5Department of Epidemiology, School of Public Health, College of Health Sciences, Aksum University, Aksum, Ethiopia; 6Department of Pharmacy, College of Medicine and Health Sciences, Adigrat University, Adigrat, Ethiopia

Correspondence: Zenawi Hagos Gufue Email [email protected]

Background: Globally, stroke appears as a major cause of preventable deaths and disabilities. In Ethiopia, the intra-hospital mortality of stroke is significant; however, epidemiologic data are scarce whether there is a difference in the overall survival time between hypertensive and non-hypertensive adult stroke patients admitted in specialized hospitals. This study was intended to determine the survival of stroke patients according to their hypertension status admitted in Ayder Comprehensive Specialized Hospital, Northern Ethiopia from March 1, 2012, to February 28, 2019.
Methods and Findings: A hospital-based retrospective cohort study was conducted among all cohorts of confirmed first-ever stroke patients admitted in Ayder Comprehensive Specialized Hospital, Northern Ethiopia. Kaplan–Meier survival analysis was applied to estimate the survival probability of hypertensive and non-hypertensive first-ever stroke patients. Cox proportional hazards regression model was used to determine the adjusted hazard ratio of death for each main baseline predictor variable with 95% CI, and P-value < 0.05 was used to declare statistical significance. The assumptions of the Cox proportional hazards regression model assessed by the global test, Schoenfeld residuals. There were 503 (323 were hypertensive, 180 Non-hypertensive) confirmed first, ever adult stroke patients, the overall median age of the patients was 65 years, IQR (53– 75) years. Seventy-five (14.9%) of them were dead, with a median survival time of 48 days and 428 (85.1%) of them were censored. At any particular point in time, the hazard of death among hypertensive patients was two times higher than non-hypertensive patients, but this was not found to be a statistically significant (adjusted HR=2.13: 95% CI 0.66– 6.81). Glasgow Coma Scale 3– 8 at admission (adjusted HR=10.12; 95% CI 2.58– 40.68), presence of stroke complications (adjusted HR=7.23; 95% CI 1.86– 28.26) and borderline high total cholesterol level (adjusted HR=3.57; 95% CI 1.15– 11.1) were the only independent predictors of intra-hospital patient mortality.
Conclusion: The overall survival time difference between hypertensive and non-hypertensive first-ever adult stroke patients was not statistically significant. Early identification and treatment of stroke complications, co-morbidities along strict follow-up of comatose patients may improve the intra-hospital survival of stroke patients, and we also recommend community-based studies using a large sample size.

Keywords: hypertension, stroke, cox regression, predictors of survival, Ethiopia

Introduction

In the previous studies, there were conflicting results in the independent survival effect of pre-stroke hypertension among adult stroke patients admitted in different specialized hospitals1 and community-based stroke registries.2 Even though the exact emergency burden of stroke in Ethiopia is not known, it has been estimated to be increasing and stroke accounts for 2.5% of all hospital admissions and 13.7% of medical admissions.3 According to the latest data published in 2017, stroke deaths in Ethiopia reached 39,571 or 6.23% of total deaths. The age-adjusted death rate of stroke accounts for 89.82 per 100,000 population.4

In Sub-Saharan Africa including Ethiopia, there are no methodologically robust stroke studies,5 and the previously conducted stroke studies in the African Continent and particularly in Ethiopia mainly focused on a descriptive summary of types, sub-types of stroke, risk profiles of patients and magnitude of risk factors. According to the latest global burden of disease report, globally there were 11.9 million new stroke cases, almost 1 in 8 deaths worldwide (12%, 6.5 million deaths) were attributable due to stroke, whereby stroke takes a life every five seconds, making stroke the second leading global cause of death.6,7

With the growing worldwide burden of stroke, someone in the world will have a stroke every two seconds.8 In the absence of a significant global public health response stroke is projected to rise to 23 million new cases and 7.8 million deaths per year by the end of 2030.9 To the best level of our knowledge (unlike western countries), we did not get studies conducted in Ethiopia on determining whether there is a difference in the survival time between hypertensive and non-hypertensive first-ever stroke patients. This study was intended to determine the survival of stroke patients according to their hypertension status admitted to Ayder Comprehensive Specialized Hospital, Northern Ethiopia.

Materials and Methods

The study was conducted in Ayder Comprehensive Specialized Hospital (ACSH), Mekelle city, Tigray Regional State, Northern Ethiopia. ACSH is a government-owned teaching hospital and research center in Northern Ethiopia, rendering its referral and specialized medical services to more than 9 million people in its catchment areas of Tigray, Afar, and North-Eastern parts of the Amhara Regional States, and Eritrean refugees.10 All patients presenting with acute neurological symptoms are initially admitted at the emergency department of the hospital and they will be investigated with Computerized Tomography (CT) scan or Magnetic Resonance Imaging (MRI). Severe cases admitted to the medical wards, and adult intensive care units, but the hospital has no stroke center and registry. The study period was seven years period from March 1, 2012 (when the hospital started using CT scan/MRI machine) to February 28, 2019, and the data extraction period was carried out from January 1 to March 31, 2019.

Study Design

A hospital-based retrospective cohort study was conducted among confirmed first-ever adult stroke patients admitted to the emergency rooms, medical wards, and adult intensive care units of the hospital with the primary diagnosis of stroke as per the World Health Organization (WHO) clinical case definition.

Sample Size Determination and Sampling Technique

The sample size was determined using two population proportion formula using Epi info version 7.2.2.6 software,11 taking hypertension status of adult stroke patients as a primary exposure variable and with the assumptions of two-sided significance level (α=5%), power (1-β) =80%, 95% confidence level, the ratio of non-exposed to exposed (R) 1:1. Accordingly, the sample size was calculated with the assumptions of percent of exposed (hypertensive) with outcome =59.2%,12 percent of non-exposed (non-hypertensive) with outcome =40.8%12 and an adjustment made for irretrievable patient medical records by taking 15%. The final sample size required to get a statistically meaningful difference between the two groups was 298. Since the total numbers of first-ever adult stroke cases were manageable (503 patients) and we want to increase, the power of the study all confirmed adult stroke cases were included in the study.

Data Collection Instrument and Process

Data were collected using a pre-tested data abstraction checklist, developed after reviewing different works of literature,13 and previous similar studies,5,14,15 then organized according to the objectives of the study. The checklist was prepared in English and for the ease of data abstraction process; it contained four parts, socio-demographics of stroke patients, antecedent risk factors of stroke, neurological factors, and acute stroke event factors. Five experienced data collectors and two supervisors were involved in the data collection process.

Operational Definitions

Definition of the Exposure Variable

Exposed group (Hypertensive patients): If a patient was taking antihypertensive medications before admission, history of being diagnosed as hypertensive by a health professional before the onset of stroke, documented blood pressure of ≥140/90 mmHg before the onset of stroke or persisting after the acute phase of the stroke. Non-exposed group (Non-hypertensive patients): It was defined as having a blood pressure reading of <140/90 mmHg before or after the onset of stroke.13

Definition of the Outcome Variable

Adult Stroke death: It was defined as recorded stroke death within the follow-up time occurring among first-ever adult stroke patients aged 18 years and above and ascertainment of death was from death records on the patient’s medical record.13 Censored: Those subjects who were discharged against medical advice, discharged with significant neurologic deficit, death other than stroke (accident or any cause not related to stroke), referred to other health facilities or event free until the end of the study whichever occurred first were considered as censored.13

Definition of the Covariates

Diabetes mellitus: It was defined as when the patient was taking any anti-diabetic medication or when a random blood sugar level of ≥ 200 mg/dL or two consecutive fasting venous plasma glucose levels of ≥ 126 mg/dL which persists beyond the acute phase of stroke (after one week of hospital admission).16

Dyslipidemia

It was defined as when the patient was taking lipid-lowering medications or a total cholesterol level of ≥ 240 mg/dL.17 Event (failure): All-cause intrahospital adult stroke death from all types of stroke which occurred within 90 days of admission.1 First-ever stroke: A stroke that occurred in persons who never had a stroke before.13

Glasgow Coma Scale (GCS)

is a 15-point neurological scale that aims to reliably and objectively record the level of consciousness of a patient (coma severity) presenting with neurologic symptoms. Interpretation of GCS is based on the score; GCS score of 13–15 (Mild brain injury), GCS score of 9–12 (Moderate brain injury), GCS score of 3–8 (Severe brain injury).18

Study Variables

The outcome variable is follow-up time in days after admission to death, whereas the independent variable is hypertension status as hypertensive and non-hypertensive. The covariates of interest were socio-demographic characteristics of adult stroke patients, antecedent risk factors of stroke, neurologic factors, stroke event factors.

Data Processing, Management, and Analysis

The collected data were coded and checked for its clarity, consistency, and completeness up to the end of each data collection period and Epi info Version 7.2.2.611 was used for data entry. The entered data was exported to STATA version 14.0.19 Descriptive statistics of numeric variables presented in medians with interquartile range (IQR), categorical variables presented using frequency and percentages, and the outcomes of each patient dichotomized into censored or dead.

The person-days of follow-up computed from admission to death, loss to follow-up, or the end of the study which occurred first. Stroke mortality rate calculated by dividing the number of deaths among first-ever stroke cases occurring to person-days of follow up. The cumulative survival rate after admission among first-ever stroke cases was estimated using the Kaplan Meier survival analysis method on day 2, day 7, day 10, day 14, and day 28 after admission to the hospital.

The observed difference in survival time between hypertensive and non-hypertensive first ever-adult stroke patients compared using the Log rank test. To assess the association among baseline variables and patient survival two strategies used, first each baseline variable that did not violate the assumptions of the Cox proportional hazards regression model entered into a separate Cox regression model. Second, a multivariable Cox proportional hazards regression model was fitted containing clinically important predictors and those variables, which had P < 0.25 in the bivariate model.20

The assumptions of the Cox proportional hazard regression model checked by the following procedures: Log (-log (St) plots, Schoenfeld residual plots, and by regressing Schoenfeld residuals against time to test for independence between time and residuals. The covariates, which violate the assumptions of the Cox proportional hazards regression model, were not included in the model and missing data, handled by simple deletion from the bivariate and multivariable analysis. The summary measures of estimated Crude Hazard Ratio (CHR) and Adjusted Hazard Ratio (AHR) with a 95% confidence interval for the survival rate among first-ever adult stroke patients estimated. P-value < 0.05 used to declare statistical significance and goodness of fit of the model assessed by the Cox-Snell residuals plot.

Results

Socio-Demographic Characteristics of Patients

Between March 1, 2012, and February 28, 2019, there were 503 cohorts of confirmed first-ever adult stroke patients admitted in Ayder Comprehensive Specialized Hospital, among these 323 (64.2%) of them were hypertensive and 180 (35.8%) of them were non-hypertensive adult stroke patients. The power of the study was 100% and the overall median age was 65 years with IQR (53–75) years. According to their exposure status, hypertensive patients’ median age was 65 years with IQR (53–75) years, among non-hypertensive patients their median age was 68 years and IQR (54–76) years.

Concerning sex distribution 252 (50.1%) of them were male patients and 285 (56.7%) of the patients were urban residents. Concerning their educational status, 500 (99.4%) patients’ educational status was not recorded. Similarly, the marital and occupational statuses of the patients were unrecorded among 481 (95.6%) and 492 (97.8%) patients’ medical records respectively (Table 1).

Table 1 Socio-Demographic Characteristics of First Ever-Adult Stroke Patients Admitted in Ayder Comprehensive Specialized Hospital, Northern Ethiopia, 2012–2019 (n=503)

Antecedent Risk Factors of Stroke

Among the 323 (64.2%) hypertensive adult stroke patients admitted, 275 (85.1%) of them were diagnosed before admission and 48 (14.9%) of them were diagnosed after hospital admission. Among those hypertensive patients diagnosed before admission, 199 (72.4%) of them were not adherent to their respective anti-hypertensive medications and the median time since when patients were told to be hypertensive was 2 years with IQR (1–5) years.

Neurological Factors

Ischemic stroke was the most common type of stroke identified among 285 (56.6%) of stroke patients and among those known sub-types of ischemic stroke, Cardio-embolic stroke was the most common sub-type identified among 69 (24.2%) ischemic stroke patients. The most frequent clinical presentations seen among first-ever adult stroke patients were hemiparesis and speech disturbances found among 397 (78.9%) and 227 (45.1%) patients respectively. Concerning the patient’s level of consciousness during hospital arrival 227 (45.1%) patients had a mild level of unconsciousness, GCS score of 13–15 (Table 2).

Table 2 Neurological Characteristics of First-Ever Adult Stroke Patients Admitted in Ayder Comprehensive Specialized Hospital, Northern Ethiopia, 2012–2019

The median duration from the onset of stroke symptoms to hospital arrival for the cohort was 24 hours with IQR (12–72) hours. According to their exposure status, the median duration from onset of stroke symptoms to hospital arrival for hypertensive patients was 24 hours, IQR (12–72) hours and for non-hypertensive patients was 48 hours, IQR (24–96) hours. Concerning the length of stay in the hospital 203 (40.4%) of the patients stayed up to two weeks and 128 (25.4%) patients stayed in the hospital for more than two weeks. Two hundred thirty-six (46.9%) of the patients develop at least one neuro-medical stroke complications, from these the top three complications were aspiration pneumonia, increased intracranial pressure (ICP) and urinary tract infection (UTI) which occurred among 183 (36.4%), 58 (11.5%) and 38 (7.6%) of stroke patients respectively (Table 3).

Table 3 Stroke Event Factors at Admission Among First-Ever Adult Stroke Patients Admitted in Ayder Comprehensive Specialized Hospital, Northern Ethiopia, 2012–2019

Survival Analysis

The total person-days of observation for the entire cohort was 5281 person-days (3380 person-days for hypertensive patients and 1901 person-days for non-hypertensive patients), with a median follow-up time of 8 days and IQR (5–14) days. According to exposure status, the median follow-up time for hypertensive patients was 8 days with IQR (5–14) days and the median follow up time for non-hypertensive patients was 9 days with IQR (5–14) days.

The overall median survival time among first ever-adult stroke patients was 48 days (95% CI; 48-not reachable), the median survival time among hypertensive patients was 48 days (95% CI 48-not reachable), the median survival time for non-hypertensive patients was not reachable, but 25% of them survive up to 25 days of admission. The median time of death for the entire cohort was four days with IQR (1–7) days. Among hypertensive patients, the median time of death was four days with IQR (1–7) days after admission.

The median time of death for non-hypertensive adult stroke patients was two days with IQR (1–7.5) days and the overall 30-day case fatality rate was 15% (74/489), among hypertensive 15.97% (50/313) and 13.64% (24/176) among non-hypertensive adult stroke patients. The cumulative survival probability for hypertensive adult stroke patients up to the end of the first week was 87% (95% CI 82–90) and by the end of the first month was 80% (95% CI 73–85). Similarly, among non-hypertensive patients was 89% (95% CI 84–94) and 73% (95% CI 55–85) respectively (Table 4).

Table 4 Kaplan – Meier Estimate of Survivor Function Among First Ever-Adult Stroke Patients Admitted in Ayder Comprehensive Specialized Hospital, Northern Ethiopia, 2012–19

A comparison of the survival curves between hypertensive and non-hypertensive adult stroke patients by Kaplan-Meier survival analysis revealed that there was no statistically significant difference in the overall survival time (Log rank test = 0.42, df =1, P= 0.52) (Figure 1). There is a statistically significant difference in the overall survival time among patients with different GCS score (Log rank test = 139.59, df=2, P<0.0001) (Figure 2). Similarly, there was a statistically significant (Log rank test 42.21, df=1, P<0.0001) difference in the survival probability of patients who developed any of the stroke complications as compared to their counterparts who did not develop any stroke complications (Figure 3).

Figure 1 Kaplan–Meier survival curve based on exposure status among first ever-adult stroke patients admitted in Ayder comprehensive specialized hospital, Northern Ethiopia, 2012–2019.

Figure 2 Kaplan–Meier survival curve based on admission Glasgow Coma Scale among first ever-adult stroke patients admitted in Ayder comprehensive specialized hospital, Northern Ethiopia, 2012–2019.

Figure 3 Kaplan–Meier survival curve based on the development of stroke complications among first ever-adult stroke patients admitted in Ayder comprehensive specialized hospital, Northern Ethiopia, 2012–2019.

Adult stroke patients who had borderline high cholesterol levels had lower cumulative survival probability as compared to those who had normal total cholesterol levels (Log rank test= 7.19, df=2, P=0.028) (Figure 4). There was also a statistically significant difference in their cumulative survival probability among the following groups of patients; urban and rural residents, Type of stroke identified, and causes of hemorrhagic stroke.

Figure 4 Kaplan–Meier survival curve based on total cholesterol level among first ever-adult stroke patients admitted in Ayder comprehensive specialized hospital, Northern Ethiopia, 2012–2019.

The multivariable Cox proportional hazards regression model shows that at any particular point in time the hazard of death among hypertensive adult stroke patients was two times higher (AHR=2.13; 95% CI 0.66–6.81) than non-hypertensive adult stroke patients by controlling the effect of other variables, but this finding was not statistically significant. The hazard of death at any particular point in time among those adult stroke patients admitted with GCS score of 3–8 had 10.12 (AHR= 10.12; 95% CI 2.58–40.68) times the higher hazard of death as compared to those who had a GCS score of 13–15, by controlling the effect of other variables (Table 5).

Table 5 Bivariate and Adjusted Predictors of Mortality Among First-Ever Adult Stroke Patients Admitted in Ayder Comprehensive Specialized Hospital, Northern Ethiopia, 2012–2019

Discussions

This study provided the first evidence on the survival of adult stroke patients and the predictors of mortality among Ethiopian first ever-adult stroke patients. There were 75 deaths (14.9%) over the seven years (with a one-month case fatality rate of 15%) out of 503 first ever-adult stroke patients. In our study, the mortality from a stroke at day 10 and 28 was 14.8 and 23.1% as compared to the study conducted in Kenya,21 the overall mortality rates were 18.4 and 26.7% respectively.

We found a non-significant difference in the overall survival time between hypertensive and non-hypertensive first ever-adult stroke patients, despite having two times the higher hazard of death among hypertensive patients. In agreement with our study, a study conducted in South London2 found that pre-stroke hypertension was not an independent predictor of patient survival and hypertensive patients had a 1% lower hazard of death as compared to non-hypertensive adult stroke patients. These findings were in contradiction with the study done in Saudi Arabia,1 whereby hypertensive patients had a 77% higher hazard of death as compared to non-hypertensive adult stroke patients. This might be due to differences in sample size, follow up period, and the proportion of hypertensive and non-hypertensive patients. In our setup hypertensive patients are somehow better resourced in terms of knowledge on their condition and are relatively better close to medical care than non-hypertensive patients.

We have found that hemorrhagic stroke was the second most common type of stroke identified among 41.55% of stroke cases which is in contrast to the study done in Addis Ababa.12 This finding is three to four times higher than the studies done in western countries.22 Hemorrhagic stroke accounts for only 10–15% of stroke cases, the possible explanations could be due to the high magnitude of hypertension in Africa and the majority of patients were not adherent to their respective anti-hypertensive medications, in our study (72.4%) all of which contribute to the high magnitude of hemorrhagic stroke.

In agreement with our findings, studies conducted in Hawassa3 and the University of Gondar,23 found that the cardio-embolic sub-type of ischemic stroke was the most common identified, indicating the dominance of the cardiac causes of ischemic stroke. There was no significant difference in the survival time among different types of stroke; the hazard of death among hemorrhagic stroke patients was 29% lower than patients who had an ischemic stroke. Similarly, the hazard of death among patients who had subarachnoid hemorrhage was 17% lower than patients who had an ischemic stroke after adjusting for the effect of age, stroke severity, and presence of stroke complications. Our finding was in line with the study done in the Netherlands.24

In our study, admission GCS score was the independent predictor of patient survival, patients who had a GCS score of 3–8 had ten times higher hazard of death as compared to those having a GCS score of 13–15. This was in line with the study done in Saudi Arabia,1 where an altered level of consciousness at presentation had a significantly higher hazard of intra-hospital mortality. Similarly, a study conducted in south London,2 found two times the higher hazard of death among patients who had moderate to severe brain injury as compared to alert patients. The possible explanation could be comatose patients had a higher probability of developing acute phase neuro-medical stroke complications, which can predispose them to a higher hazard of death. This finding had a clinical significance during patient management, as it affects the length of stay, the functional outcome of the patient, and overall costs of stroke treatment.

We found that at any particular point in time, the hazard of death among adult stroke patients who had any of the neuro-medical stroke complications was seven times higher than those who had no complications, after adjusting for potential confounders. This finding was in line with the studies done in Italy,25 Taiwan,26 Saudi Arabia,1 this can be explained by the effect of stroke-related depressed immunity; depressed gag-reflex, and delayed mobilization of admitted patients. Early management of complications along with early mobilization and rehabilitation of patients, could significantly lower the incidence of complications, shortens the length of hospital stay and disability after the onset of stroke symptoms.

Adult stroke patients who had a total cholesterol level of borderline high had almost four times the higher hazard of death as compared to patients who had normal total cholesterol levels. A non-significant difference in the hazard of death observed between patients who had high and normal total cholesterol levels, despite having a 57% higher hazard of death among patients who had a high total cholesterol level. This was different from the study conducted in Sweden,27 a high total cholesterol level was an independent predictor of improved long-term survival of ischemic stroke patients. This improved survival among high cholesterol patients created a sense of obesity paradox.

This was the first local study, which tried to determine the survival of stroke patients according to hypertension status by following the minimum gold standard recommendations of Epidemiologic stroke study,5 and reporting of quality survival analysis data.28 We separately reported the number of first-ever and recurrent cases, we had used only confirmed stroke cases, World Health Organization clinical case definition of stroke, stroke type and sub-types along with the adjusted estimate of predictor variables. The cohort groups were also comparable in most of their baseline characteristics.

The result of this study was not without limitations. First, the study was limited to adult stroke patients who present to the hospital, we cannot rule out potential selection bias (referral bias) for those who died out of the hospital. There was also a significant missing of socio-demographic variables; we excluded them from the Cox regression model, which might affect the adjusted estimates of covariates. We studied all-cause mortalities; we were not able to determine the exact causes of death for each admitted patient, which would imply patient management, by acknowledging these potential limitations we hope that this finding can serve as baseline information for further research.

Conclusions

We have found that there was no statistically significant difference in survival time between hypertensive and non-hypertensive first-ever adult stroke patients. The exposure status does not matter for patient survival rather; Glasgow Coma Scale at admission, presence of stroke complications, and borderline high total cholesterol level were the independent predictors of patient mortality.

Data Sharing Statement

The datasets generated and analyzed during the current study are available from the corresponding author on a reasonable request.

Ethics Approval and Informed Consent

Ethical approval was obtained from Mekelle University, Health Research Ethics Review Committee (ERC 1220/2019). The data collected from the medical records were handled with strong confidentiality, neither the case records nor the data extracted were used for any other purpose and all the collected patient information was stored anonymously. The study was conducted following the Declaration of Helsinki.

Author Contributions

All authors made substantial contributions to conception and design, acquisition of data, or analysis and interpretation of data; took part in drafting the article or revising it critically for important intellectual content; gave final approval of the version to be published; and agree to be accountable for all aspects of the work.

Disclosure

The authors report no conflicts of interest in this work.

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