Back to Journals » Clinical Ophthalmology » Volume 7

Surgical therapy versus observation for lamellar macular hole: a retrospective comparison study

Authors Sanisoglu H, Elbay A, Sevim S, Celik U, Aktas FB, Durmus E

Received 4 April 2013

Accepted for publication 5 August 2013

Published 18 September 2013 Volume 2013:7 Pages 1843—1848


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Huseyin Sanisoglu,1 Ahmet Elbay,2 Sahin Sevim,1 Ugur Celik,3 Fatma B Aktas,1 Ebubekir Durmus1

1Department of Ophthalmology, Haydarpasa Training and Research Hospital, 2Department of Ophthalmology, Pendik Government Hospital, 3Department of Ophthalmology, Beyoglu Eye Training and Research Hospital, Istanbul, Turkey

Background: The purpose of this study was to compare anatomic and visual changes in patients with lamellar macular hole undergoing pars plana vitrectomy with those in patients undergoing follow-up only.
Methods: In this retrospective consecutive case series study, we evaluated two groups of eyes, comprising 19 eyes from 19 patients with lamellar macular hole who underwent pars plana vitrectomy with internal limiting membrane peeling and 21 eyes from 21 patients with lamellar macular hole who had follow-up only. Corrected distance visual acuity (CDVA, in logMAR) and optical coherence tomography findings, including measurements of maximum diameter of lamellar defect and foveal thickness, and whether the inner segment/outer segment band was intact or not were documented at initial and follow-up examinations.
Results: At initial examination, mean CDVA was 0.54 logMAR in the study group and 0.51 logMAR in the control group, and 0.33 logMAR and 0.55 logMAR, respectively, on final examination. In the study group, postoperative optical coherence tomography images were found to be normalized in ten patients (52.6%), improved in six (31.5%), unchanged in two (10.5%), and to have progressed to full-thickness macular hole in one (5.2%) in the intervention group, while all patients in the control group were found to have deteriorated within the follow-up period between March 2004 and June 2010.
Conclusion: In patients with lamellar macular hole, combination treatment with pars plana vitrectomy and internal limiting membrane peeling appears to be effective, but further studies are required to establish new treatment modalities for patients who do not have a satisfactory outcome from treatment.

Keywords: lamellar macular hole, pars plana vitrectomy, internal limiting membrane peeling, outcome

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]


Other articles by this author:

Evaluation of the relationship between corneal biomechanic and HbA1C levels in type 2 diabetes patients

Yazgan S, Celik U, Kaldirim H, Ayar O, Elbay A, Aykut V, Celik B, Taş M

Clinical Ophthalmology 2014, 8:1549-1553

Published Date: 19 August 2014

Femtosecond lenticule extraction for correction of myopia: a 6 month follow-up study

Demirok A, Agca A, Ozgurhan EB, Bozkurt E, Celik U, Demircan A, Guleryuz NB, Cankaya KI, Yilmaz OF

Clinical Ophthalmology 2013, 7:1041-1047

Published Date: 7 June 2013

Accuracy and precision of cap thickness in small incision lenticule extraction

Ozgurhan EB, Agca A, Bozkurt E, Gencer B, Celik U, Cankaya KI, Demirok A, Yilmaz OF

Clinical Ophthalmology 2013, 7:923-926

Published Date: 21 May 2013

Readers of this article also read:

Green synthesis of water-soluble nontoxic polymeric nanocomposites containing silver nanoparticles

Prozorova GF, Pozdnyakov AS, Kuznetsova NP, Korzhova SA, Emel’yanov AI, Ermakova TG, Fadeeva TV, Sosedova LM

International Journal of Nanomedicine 2014, 9:1883-1889

Published Date: 16 April 2014

Methacrylic-based nanogels for the pH-sensitive delivery of 5-Fluorouracil in the colon

Ashwanikumar N, Kumar NA, Nair SA, Kumar GS

International Journal of Nanomedicine 2012, 7:5769-5779

Published Date: 15 November 2012

A novel preparation method for silicone oil nanoemulsions and its application for coating hair with silicone

Hu Z, Liao M, Chen Y, Cai Y, Meng L, Liu Y, Lv N, Liu Z, Yuan W

International Journal of Nanomedicine 2012, 7:5719-5724

Published Date: 12 November 2012

Cross-linked acrylic hydrogel for the controlled delivery of hydrophobic drugs in cancer therapy

Deepa G, Thulasidasan AK, Anto RJ, Pillai JJ, Kumar GS

International Journal of Nanomedicine 2012, 7:4077-4088

Published Date: 27 July 2012

Crystallization after intravitreal ganciclovir injection

Pitipol Choopong, Nattaporn Tesavibul, Nattawut Rodanant

Clinical Ophthalmology 2010, 4:709-711

Published Date: 14 July 2010