Surgical Compliance and Survival Outcomes for Patients with Stage T1-2 Non-Small-Cell Lung Cancer
Received 15 November 2019
Accepted for publication 27 April 2020
Published 19 May 2020 Volume 2020:12 Pages 3597—3610
Checked for plagiarism Yes
Review by Single-blind
Peer reviewer comments 2
Editor who approved publication: Dr Beicheng Sun
Siben Wang,1,* Weipu Mao,2,* Yi Wang,3,* Xiuquan Shi,4 Wei Wang,3 Lili Dai,3 Wenping Zhang1
1Department of Thoracic Surgery, Heping Hospital Affiliated to Changzhi Medical College, Changzhi, Shanxi Province 046000, People’s Republic of China; 2Department of Urology, Affiliated Zhongda Hospital of Southeast University, Nanjing 210009, People’s Republic of China; 3Department of Respiratory Medicine, The Forth Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province 230022, People’s Republic of China; 4Department of General Surgery, The People’s Hospital of Yingshang, Fuyang, Anhui Province 236200, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Wenping Zhang; Lili Dai Tel/Fax +86-134035580000
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Introduction: Our aim was to determine the relationship between surgical compliance and survival outcomes in patients with stage T1-2 non-small-cell lung cancer (NSCLC).
Methods: Patients with T1-2 NSCLC who were diagnosed between 2004 and 2015 were identified from the SEER database. Multivariate logistic regression was used to analyse factors associated with surgical compliance. Kaplan–Meier curves and Cox regression were used to analyse the effects of surgical compliance on overall survival (OS) and cancer-specific survival (CSS).
Results: Of the 221,704 eligible T1-2 NSCLC patients, 106,668 patients recommended surgery. Among them, 99,672 (93.4%) patients were surgical compliance group, and 6996 (6.6%) were surgical noncompliance group. Poor surgical compliance was associated with earlier diagnosis time, old age, male, black race, unmarried status, main bronchus site, poor grade/stage, and lower household income. Patients’ compliance was an independent prognostic factor for OS and CSS of T1-2 NSCLC patients. Multivariate Cox regression showed that surgical noncompliance individuals showed lower OS (hazard ratio [HR] 2.494; 95% confidence interval [CI] 2.423– 2.566, p < 0.001) and lower CSS (HR 2.877; 95% CI 2.782– 2.974, p < 0.001) compared with surgical compliance patients. In addition, results in the non-surgical group were observed to be similar to those of the surgical noncompliance group.
Conclusion: We found that patients’ compliance was an independent prognostic factor for survival in T1-2 NSCLC patients. Poor surgical compliance was associated with earlier diagnosis time, old age, male, black race, unmarried status, main bronchus site, poor grade/stage, and lower household income.
Keywords: non-small-cell lung cancer, surgical compliance, survival outcome, SEER
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