Surface activity of surfactant spiked with vitamin A
Vadim Bronshtein, Vugranam Venkatesh, Jas Aulakh, Philippe Chessex
Division of Neonatology, Children’s and Women’s Health Centre of British Columbia, University of British Columbia, Vancouver, BC, Canada
Background: Intramuscular injections of vitamin A decrease the risk of broncho-pulmonary dysplasia. Admixture of vitamin A with surfactant as a lipophilic vehicle might be a less invasive modality.
Aim: Test physical properties of surfactant + vitamin A.
Methods: Miscibility and surface activity were tested in surfactant supplemented with retinyl-acetate, -palmitate, 13-cis-, or all-trans-retinoic acid.
Results: Retinol acetate (5000 IU/mL) demonstrated miscibility with surfactant when premixing with ethanol. Its surface activity was 40% lower compared to surfactant alone.
Conclusion: These findings warrant preclinical studies to test whether administration of vitamin A in subjects requiring surfactant is associated with beneficial functional properties.
Keywords: drug delivery, vitamin A, surfactant, surface tension
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