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Sudden bilateral hearing loss in gastric cancer as the only symptom of disease

Authors Rakusic Z, Misir Krpan A, Polancec D, Jakovcevic A, Bisof V

Received 11 February 2015

Accepted for publication 1 April 2015

Published 2 June 2015 Volume 2015:8 Pages 1285—1289


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4

Editor who approved publication: Professor Daniele Santini

Zoran Rakusic,1 Ana Misir Krpan,1 Darija Stupin Polancec,2 Antonia Jakovcevic,3 Vesna Bisof1

1Department of Oncology, University Hospital Center Zagreb, 2Fidelta Ltd for Research and Development, 3Department of Pathology, University Hospital Center Zagreb, Zagreb, Croatia

Abstract: This paper reports a case of sudden bilateral deafness as the first symptom of gastric cancer, an extremely rare and atypical clinical situation. Because common signs of stomach cancer were absent, the patient was first evaluated in the Department of Otolaryngology, University Hospital Center, Zagreb. Only after expanded diagnostic evaluation and rapid progression of the disease in such a case is a malignant tumor suspected. Treatment is mostly ineffective. The unusual presentation of the disease and the rapid course may indicate a hereditary predisposition. Inactivation of tumor suppressor gene DFNA5 was found in 50% of gastric cancers, but of a non-metastasized phenotype. Inactivated DFNA5, otherwise described in hereditary bilateral deafness, perhaps favors the development of deafness in patients with gastric cancer. Our patient had a positive multiple viral antibody titer in serum, inactivated DFNA5 in both gastric cancer tissues and cerebellar metastases, and a metastatic form of the disease. If sudden deafness occurs in elderly patients, the possibility of malignant tumor should be taken into consideration. The link between gastric cancer and the DFNA5 gene is unclear and requires further research.

Keywords: deafness, gastric cancer, DFNA5 gene, meningeal carcinomatosis
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