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Successful treatment of prosthetic pulmonary valve thrombosis with reteplase: a case report

Authors Khameneh Bagheri R, Keihanian F, Ahmadi M, Ansari MA

Received 22 March 2018

Accepted for publication 26 June 2018

Published 6 September 2018 Volume 2018:11 Pages 205—208

DOI https://doi.org/10.2147/IMCRJ.S168968

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Andrew Yee

Peer reviewer comments 4

Editor who approved publication: Professor Ronald Prineas


Ramin Khameneh Bagheri1 Faeze Keihanian,2,3 Mostafa Ahmadi,1 Mohammad Ali Ansari2

1Atherosclerosis Prevention Research Center, Imam Reza Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; 2Cardiology Department, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; 3Pharmaceutical Research Division, Booali Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Abstract: Pulmonary prosthetic valve thrombosis is a serious and rare complication with high mortality. Using reteplase for treatment of prosthesis thrombosis is rarely reported. We report the first case in Iran of a thrombosed pulmonary valve in a patient who had undergone repair of tetralogy of Fallot, which was successfully treated twice with intravenous thrombolytic therapy with reteplase.

Keywords: pulmonary valve thrombosis, reteplase, thrombolysis, recombinant plasminogen activator

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