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Successful treatment of neovascular age-related macular degeneration following single bevacizumab failure using aflibercept in a vitrectomized eye

Authors Hahn P

Received 26 August 2014

Accepted for publication 17 September 2014

Published 17 October 2014 Volume 2014:8 Pages 2129—2131

DOI https://doi.org/10.2147/OPTH.S73265

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Dr Scott Fraser


Paul Hahn

Duke Eye Center, Duke University Medical Center, Durham, NC, USA

Abstract: Intravitreal anti-vascular endothelial growth factor (VEGF) pharmacotherapy in vitrectomized eyes remains a challenge due to the reduced half-life of these agents. Aflibercept may have stronger binding activity and a longer intravitreal half-life compared to bevacizumab and ranibizumab, but its use in postvitrectomy eyes has not been reported. We present a case of an 89-year-old female, with recurrent choroidal neovascularization 10 years following prior macular translocation vitrectomy surgery for neovascular age-related macular degeneration, successfully treated with monthly aflibercept injections initiated following poor response to a single initial bevacizumab injection. This report suggests that aflibercept may be an important treatment option for vitrectomized eyes requiring anti-VEGF treatment.

Keywords: anti-VEGF, vitrectomized, aflibercept, neovascular age-related macular degeneration
 

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