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Successful mobilization of peripheral blood stem cells in children with cancer using plerixafor (Mozobil™) and granulocyte-colony stimulating factor

Authors Avramova B, Yordanova, Konstantinov, Bobev

Published 26 August 2011 Volume 2011:5 Pages 407—409

DOI https://doi.org/10.2147/DDDT.S19157

Review by Single-blind

Peer reviewer comments 3


Boryana E Avramova, Maya N Yordanova, Dobrin N Konstantinov, Dragan G Bobev
Specialized Hospital for Treatment of Children with Onco-Haematological Diseases, Sofia, Bulgaria

Abstract: This paper describes the successful mobilization of peripheral blood stem cells for autologous transplantation in three children with malignant diseases by using plerixafor (Mozobil™; Genzyme Corporation, Cambridge, MA) and granulocyte-colony stimulating factor (G-CSF) after failed previous mobilizations. A median sixfold increase in the number of circulating CD34+ cells after plerixafor treatment as compared with the baseline level was observed. An optimal CD34+ cell count for transplantation with one or two leukapheresis sessions was achieved. Mobilization using plerixafor was found to be safe with no adverse events. Therefore, the combination of G-CSF and plerixafor in children results in effective increases in peripheral CD34+ cell counts and reduces the risk of mobilization failure.

Keywords: stem cells, mobilization, plerixafor, children, G-CSF
 

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