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Successful management of Barth syndrome: a systematic review highlighting the importance of a flexible and multidisciplinary approach

Authors Reynolds S

Received 6 May 2015

Accepted for publication 28 May 2015

Published 29 July 2015 Volume 2015:8 Pages 345—358

DOI https://doi.org/10.2147/JMDH.S54802

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Dr Scott Fraser

Stacey Reynolds

Department of Occupational Therapy, Virginia Commonwealth University, Richmond, VA, USA

Abstract: This review describes and summarizes the available evidence related to the treatment and management of Barth syndrome. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) standards were used to identify articles published between December 2004 and January 2015. The Cochrane Population, Intervention, Control, Outcome, Study Design (PICOS) approach was used to guide the article selection and evaluation process. Of the 128 articles screened, 28 articles matched the systematic review inclusion criteria. The results of this review indicate the need for a flexible and multidisciplinary approach to manage the symptoms most commonly associated with Barth syndrome. It is recommended that a comprehensive care team should include individuals with Barth syndrome, their family members and caregivers, as well as medical, rehabilitative, nutritional, psychological, and educational professionals. The evidence for specific treatments, therapies, and techniques for individuals with Barth syndrome is currently lacking in both quality and quantity.

Keywords: Barth syndrome, rare disorders, rehabilitation, cardiac, systematic review

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