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Success with neurotropin in treating pediatric lower extremity pain induced by spinal cord injury after epidural anesthesia

Authors Zhu MY, Zhou F, Li L, Yin Q, Qiu M, Zhang Y

Received 18 February 2017

Accepted for publication 20 April 2017

Published 6 June 2017 Volume 2017:10 Pages 1391—1394

DOI https://doi.org/10.2147/JPR.S135037

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Lucy Goodman

Peer reviewer comments 2

Editor who approved publication: Dr E. Alfonso Romero-Sandoval

Mengye Zhu,1,* Fuqing Zhou,2,* Lingchao Li,1 Qin Yin,3 Mizhen Qiu,1 Yong Zhang1

1Department of Pain Clinic, 2Department of Radiology, The First Affiliated Hospital of Nanchang University, Nanchang, 3Department of Pain Clinic, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, People’s Republic of China

*These authors contributed equally to this work

Abstract: Spinal cord injury (SCI) complicated by epidural anesthesia, though rare, can result in neuropathic pain. However, the treatment for this kind of life-altering injury remains a challenge. A 7-year-old girl was referred with dyskinesia and severe pain in her right lower extremity due to an accidental SCI following lumbar puncture. After treatment with analgesics such as gabapentin, mecobalamin, and dexamethasone/methylprednisolone for 1 week, the myodynamia had improved, but progressive pain persisted. After treatment with neurotropin, a gradual decrease in visual analog scale score from 7 to 0 was observed. We herein first describe that neurotropin produced sustained relief of pain induced by SCI. This case suggests that neurotropin might be a promising drug in treating pediatric neuropathic pain caused by SCI.

Keywords: spinal cord injury, pain, neurotropin, children

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