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Subacute toxicity of cadmium on hepatocytes and nephrocytes in the rat could be considered as a green biosynthesis of nanoparticles

Authors Trabelsi H, Azzouz I, Sakly M, Abdelmelek H

Received 22 October 2012

Accepted for publication 22 December 2012

Published 14 March 2013 Volume 2013:8(1) Pages 1121—1128

DOI https://doi.org/10.2147/IJN.S39426

Checked for plagiarism Yes

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Peer reviewer comments 4

Hamdi Trabelsi, Inès Azzouz, Mohsen Sakly, Hafedh Abdelmelek
Laboratory of Physiologie Intégrée, Faculty of Sciences of Bizerte, Carthage University, Tunisia

Abstract: The purpose was to study the toxicity of cadmium (Cd) and to explore its potential to generate nanoparticles during detoxification. In order to demonstrate this, in vivo fluorescence imaging, X-ray diffraction, and flow cytometry were performed. The in vivo imaging showed a fluorescence signal after Cd treatment (CdCl2, 1.50 mg/Kg, intraperitoneally). By contrast, the control-rat fluorescence was negative. The fluorescence was divided into three colors, red, yellow, and green, and probably indicates the presence of quantum dots. X-ray diffraction results revealed the presence of Cd sulfide (CdS) and/or Cd selenide (CdSe) nanoparticles following Cd injection in the liver (6.52 nm) and kidneys (56.30 nm). Interestingly, flow cytometry revealed a heterogeneous size distribution and a homogeneous granularity of synthesized nanoparticles. Using the green fluorescence channel and the red fluorescence channel, a narrow green emission spectrum and a broad red emission spectrum were detected, respectively, by cytometric analysis.

Keywords: XRD, in vivo imaging, flow cytometry, quantum dots, cadmium sulfide, cadmium selenide

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Nanotoxicological evaluation of oxidative responses in rat nephrocytes induced by cadmium

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