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Study on Risk Factors of Diabetic Nephropathy in Obese Patients with Type 2 Diabetes Mellitus

Authors Hu F, Zhang T

Received 27 March 2020

Accepted for publication 21 June 2020

Published 6 July 2020 Volume 2020:13 Pages 351—360


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Dr Scott Fraser

Fan Hu,* Taotao Zhang*

School of Public Health, Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of China

*These authors contributed equally to this work

Correspondence: Fan Hu
School of Public Health, Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of China
Tel/ Fax +86215132246

Purpose: The purpose of this study was to identify diabetic nephropathy risk factors in type 2 diabetes mellitus obese people based on community type 2 diabetes mellitus patients.
Patients and Methods: In the community in Shanghai, we conduct a questionnaire, physical examination, and biochemical examination. The 406 patients included in the analysis were divided into two groups based on whether or not they had diabetic nephropathy. The influencing factors of type 2 diabetes mellitus obese patients were screened by the least absolute shrinkage and selection operator method, and then the influencing factors detected by the least absolute shrinkage and selection operator method were included in the binary logistic regression analysis, and the risk factors for diabetic nephropathy in obese people with type 2 diabetes mellitus were obtained. Finally, the nomogram and forest plot are used to visualize the binary logistic regression results, and the calibration plot and receiver-operating characteristic curve are used to verify the result.
Results: The results showed that family history of diabetes (OR= 2.091, P= 0.002), disease course (OR=1.050, P= 0.007). hypertension (OR=1.768, P=0.042), hyperuricemia (OR=2.263, P=0.003), systolic blood pressure (OR=1.027, P< 0.001), and glycosylated haemoglobin A1c (OR=1.358, P< 0.001) were risk factors for diabetic nephropathy.
Conclusion: For obese patients with type 2 diabetes mellitus, they should pay attention to family history of diabetes, disease course and hyperuricemia. Hypertension should be concerned and strictly controlled. Systolic blood pressure and glycosylated haemoglobin A1c will help prolong the survival of diabetic nephropathy patients.

Keywords: obesity, type 2 diabetes mellitus, risk factors, diabetic nephropathy

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