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Structural and magnetic properties of cobalt-doped iron oxide nanoparticles prepared by solution combustion method for biomedical applications

Authors Venkatesan K, Babu DR, Bai M, Supriya R, Vidya R, Madeswaran S, Anandan P, Arivanandhan M, Hayakawa Y

Received 21 March 2015

Accepted for publication 2 June 2015

Published 1 October 2015 Volume 2015:10(Supplement 1 Challenges in biomaterials research) Pages 189—198

DOI https://doi.org/10.2147/IJN.S82210

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Dr Thomas Webster


Kaliyamoorthy Venkatesan,1 Dhanakotti Rajan Babu,1 Mane Prabhu Kavya Bai,2 Ravi Supriya,2 Radhakrishnan Vidya,2 Saminathan Madeswaran,1 Pandurangan Anandan,3 Mukannan Arivanandhan,3 Yasuhiro Hayakawa3

1School of Advanced Sciences, 2School of Bio Sciences and Technology, VIT University, Vellore, Tamil Nadu, India; 3Research Institute of Electronics, Shizuoka University, Hamamatsu, Japan

Abstract: Cobalt-doped iron oxide nanoparticles were prepared by solution combustion technique. The structural and magnetic properties of the prepared samples were also investigated. The average crystallite size of cobalt ferrite (CoFe2O4) magnetic nanoparticle was calculated using Scherrer equation, and it was found to be 16±5 nm. The particle size was measured by transmission electron microscope. This value was found to match with the crystallite size calculated by Scherrer equation corresponding to the prominent intensity peak (311) of X-ray diffraction. The high-resolution transmission electron microscope image shows clear lattice fringes and high crystallinity of cobalt ferrite magnetic nanoparticles. The synthesized magnetic nanoparticles exhibited the saturation magnetization value of 47 emu/g and coercivity of 947 Oe. The anti-microbial activity of cobalt ferrite nanoparticles showed better results as an anti-bacterial agent. The affinity constant was determined for the nanoparticles, and the cytotoxicity studies were conducted for the cobalt ferrite nanoparticles at different concentrations and the results are discussed.

Keywords: cytotoxicity, HR-TEM, magnetic nanoparticles, VSM
 

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