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Strong topical steroid, NSAID, and carbonic anhydrase inhibitor cocktail for treatment of cystoid macular edema

Authors Asahi M, Dogaru G, Onishi S, Gallemore R

Received 21 July 2015

Accepted for publication 27 August 2015

Published 1 December 2015 Volume 2015:8 Pages 305—312

DOI https://doi.org/10.2147/IMCRJ.S92794

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Yusuke Okuma

Peer reviewer comments 4

Editor who approved publication: Dr Scott Fraser


Masumi G Asahi, Gabriela L Bobarnac Dogaru, Spencer M Onishi, Ron P Gallemore

Retina Macula Institute, Torrance, CA, USA

Purpose: To report the combination cocktail of strong steroid, non-steroidal anti-inflammatory drug (NSAID), and carbonic anhydrase inhibitor drops for treatment of cystoid macular edema.
Methods: This is a retrospective case series of patients with cystoid macular edema managed with a topical combination of strong steroid (difluprednate), NSAID, and carbonic anhydrase inhibitor drops. The patients were followed with optical coherence tomography and fluorescein angiography.
Results: In our six cases, resolution of the cystic edema with improvement in visual acuity was achieved with the use of a combination cocktail of drops. Leakage on fluorescein angiography and cystic edema on optical coherence tomography both responded to treatment with the topical cocktail of drops.
Conclusion: A topical cocktail of strong steroid, NSAID, and carbonic anhydrase inhibitor drops are effective for managing cystoid macular edema. Further studies comparing this combination with more invasive treatments should be undertaken to determine the efficacy of this cocktail over other treatment options.

Keywords: birdshot chorioretinopathy, diabetic macular edema, retinal vein occlusion

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