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Stroke subtype, age, and baseline NIHSS score predict ischemic stroke outcomes at 3 months: a preliminary study from Central Nepal

Authors Shrestha S, Poudel R, Khatiwada D, Thapa L

Received 16 June 2015

Accepted for publication 22 August 2015

Published 1 October 2015 Volume 2015:8 Pages 443—448


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Dr Scott Fraser

Shakti Shrestha,1 Ramesh Sharma Poudel,2 Dipendra Khatiwada,3 Lekhjung Thapa4

1Department of Pharmacy, Shree Medical and Technical College, 2Department of Pharmacy, 3Department of Community Medicine, 4Department of Neurology, College of Medical Sciences-Teaching Hospital, Chitwan, Nepal

Background: The combined medications practice of using antithrombotic agents and statins with or without antihypertensive agents is common in the treatment of acute ischemic stroke in Nepal. Short-term outcomes of the current practice have been studied. We aim to explore the predictors of ischemic stroke outcomes at 3 months, with the current combined medications practice.
Methods: The study population (N=56) included acute ischemic stroke patients treated at the Neurology Department of the College of Medical Sciences-Teaching Hospital, Chitwan, Nepal, from May 2014 to August 2014 and followed up at 3 months. Death or disability (modified Rankin scale >2) was defined as poor outcomes. Multivariate logistic regression analysis (P<0.10) using potential variables from bivariate analysis (P≤0.20) was adjusted to predict outcomes at 3 months.
Results: At 3 months, 29 (51.8%) patients were independent, eleven (19.6%) were dependent, while 16 (28.6%) died. Stroke subtype and baseline National Institute of Health Stroke Scale (NIHSS) scores were associated with death/disability (27, 48.2%) at 3 months. Regression analysis showed that large-artery stroke (odds ratio [OR] =284.145, 95% confidence interval [CI] =5.221–15,465.136, P=0.006), age (OR =1.113, 95% CI =1.002–1.236, P=0.045), and baseline NIHSS score (OR =1.557, 95% CI =1.194–2.032, P=0.001) were significant predictors of poor outcome at 3 months.
Conclusion: Stroke subtype, age, and baseline NIHSS score are predictors of ischemic stroke outcomes in Nepalese population treated with the current practice of using combined antithrombotic and statins with or without antihypertensive agents, and these predictors can be used for the improvement of selection of patients for the appropriate treatment.

Keywords: age, Nepal, NIHSS score, ischemic stroke, stroke subtype

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