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Stroke prevention in the elderly atrial fibrillation patient with comorbid conditions: focus on non-vitamin K antagonist oral anticoagulants

Authors Turagam MK, Velagapudi P, Flaker G

Received 14 May 2015

Accepted for publication 10 July 2015

Published 3 September 2015 Volume 2015:10 Pages 1431—1444

DOI https://doi.org/10.2147/CIA.S80641

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Dr Richard Walker

Mohit K Turagam, Poonam Velagapudi, Greg C Flaker

Division of Cardiovascular Medicine, University of Missouri School of Medicine, Columbia, MO, USA

Abstract:
Stroke prevention in elderly atrial fibrillation patients remains a challenge. There is a high risk of stroke and systemic thromboembolism but also a high risk of bleeding if anticoagulants are prescribed. The elderly have increased chronic kidney disease, coronary artery disease, polypharmacy, and overall frailty. For all these reasons, anticoagulant use is underutilized in the elderly. In this manuscript, the benefits of non-vitamin K antagonist oral anticoagulants compared with warfarin in the elderly patient population with multiple comorbid conditions are reviewed.

Keywords: non-vitamin K antagonist oral anticoagulants, novel oral anticoagulants, warfarin, dabigatran, rivaroxaban, apixaban, edoxaban

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