Back to Journals » International Journal of Nanomedicine » Volume 13

Stimuli-responsive polymeric micelles for drug delivery and cancer therapy

Authors Zhou Q, Zhang L, Yang T, Wu H

Received 2 December 2017

Accepted for publication 13 March 2018

Published 18 May 2018 Volume 2018:13 Pages 2921—2942

DOI https://doi.org/10.2147/IJN.S158696

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Cristina Weinberg

Peer reviewer comments 2

Editor who approved publication: Dr Linlin Sun


Qing Zhou,1,* Li Zhang,2,* TieHong Yang,1 Hong Wu1

1Department of Pharmaceutical Analysis, School of Pharmacy, Air Force Military Medical University, Xi’an, People’s Republic of China; 2State Key Laboratory of Military Stomatology, Air Force Military Medical University, Xi’an, People’s Republic of China

*These authors contributed equally to this work

Abstract:
Polymeric micelles (PMs) have been widely investigated as nanocarriers for drug delivery and cancer treatments due to their excellent physicochemical properties, drug loading and release capacities, facile preparation methods, biocompatibility, and tumor targetability. They can be easily engineered with various functional moieties to further improve their performance in terms of bioavailability, circulation time, tumor specificity, and anticancer activity. The stimuli-sensitive PMs capable of responding to various extra- and intracellular biological stimuli (eg, acidic pH, altered redox potential, and upregulated enzyme), as well as external artificial stimuli (eg, magnetic field, light, temperature, and ultrasound), are considered as “smart” nanocarriers for delivery of anticancer drugs and/or imaging agents for various therapeutic and diagnostic applications. In this article, the recent advances in the development of stimuli-responsive PMs for drug delivery, imaging, and cancer therapy are reviewed. The article covers the generalities of stimuli-responsive PMs with a focus on their major delivery strategies and newly emerging technologies/nanomaterials, discusses their drawbacks and limitations, and provides their future perspectives.

Keywords: nanomedicine, polymeric micelles, stimuli-responsive, drug delivery, cancer therapy

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]