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Stereotactic body radiation therapy for pulmonary large cell neuroendocrine carcinoma: a case report

Authors Jo IY, Yeo SG

Received 5 October 2018

Accepted for publication 20 January 2019

Published 18 February 2019 Volume 2019:12 Pages 1359—1364

DOI https://doi.org/10.2147/OTT.S189858

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 2

Editor who approved publication: Dr XuYu Yang


In Young Jo, Seung-Gu Yeo

Department of Radiation Oncology, Soonchunhyang University College of Medicine, Soonchunhyang University Hospital, Cheonan, Republic of Korea

Abstract: The incidence of large cell neuroendocrine carcinoma (LCNEC) of the lung is rare, and the treatment methods and prognosis for such patients are still subjects of debate. We report a case of a 78-year-old male LCNEC patient for whom stereotactic body radiation therapy was performed. A four-dimensional computed tomography scan was used for simulation, and radiotherapy was planned using the volumetrically modulated arc technique. A total of 55 Gy was delivered in five daily fractions. The treatment was safely completed, and the patient did not report any discomfort. The only side-effect was an intermittent cough. Currently, the patient has received 18 months of outpatient follow-up care with no evidence of disease. In conclusion, stereotactic body radiation therapy can be a valuable treatment option for early stage LCNEC.

Keywords: lung, large cell, neuroendocrine carcinoma, stereotactic ablative radiotherapy, radiation therapy

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