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Stepwise encapsulation and controlled two-stage release system for cis-Diamminediiodoplatinum

Authors Chen Y, Li Q, Wu QS

Received 29 January 2014

Accepted for publication 9 April 2014

Published 28 June 2014 Volume 2014:9(1) Pages 3175—3182

DOI https://doi.org/10.2147/IJN.S61570

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Yun Chen,1,* Qian Li,1,2,* Qingsheng Wu1

1Department of Chemistry, Key Laboratory of Yangtze River Water Environment, Ministry of Education, Tongji University, Shanghai; 2Shanghai Institute of Quality Inspection and Technical Research, Shanghai, People’s Republic of China

*These authors contributed equally to this work

Abstract: cis-Diamminediiodoplatinum (cis-DIDP) is a cisplatin-like anticancer drug with higher anticancer activity, but lower stability and price than cisplatin. In this study, a cis-DIDP carrier system based on micro-sized stearic acid was prepared by an emulsion solvent evaporation method. The maximum drug loading capacity of cis-DIDP-loaded solid lipid nanoparticles was 22.03%, and their encapsulation efficiency was 97.24%. In vitro drug release in phosphate-buffered saline (pH =7.4) at 37.5°C exhibited a unique two-stage process, which could prove beneficial for patients with tumors and malignancies. MTT (3-[4,5-dimethylthiazol-2-yl]-2, 5-diphenyltetrazolium bromide) assay results showed that cis-DIDP released from cis-DIDP-loaded solid lipid nanoparticles had better inhibition activity than cis-DIDP that had not been loaded.

Keywords: stearic acid, emulsion solvent evaporation method, drug delivery, cis-DIDP, in vitro

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