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Stem cell-mediated osteogenesis: therapeutic potential for bone tissue engineering

Authors Neman J, Hambrecht A, Cadry, Jandial R

Received 8 May 2011

Accepted for publication 29 June 2011

Published 9 March 2012 Volume 2012:6 Pages 47—57


Review by Single-blind

Peer reviewer comments 3

Josh Neman1, Amanda Hambrecht2, Cherie Cadry3, Rahul Jandial1

1Department of Neurosurgery, Beckman Research Institute, City of Hope National Cancer Center, Duarte, 2Department of Biological Sciences, University of Southern California, Los Angeles, 3Department of Public Health Sciences, University of California, Irvine, California, USA

Abstract: Intervertebral disc degeneration often requires bony spinal fusion for long-term relief. Current arthrodesis procedures use bone grafts from autogenous bone, allogenic backed bone, or synthetic materials. Autogenous bone grafts can result in donor site morbidity and pain at the donor site, while allogenic backed bone and synthetic materials have variable effectiveness. Given these limitations, researchers have focused on new treatments that will allow for safe and successful bone repair and regeneration. Mesenchymal stem cells have received attention for their ability to differentiate into osteoblasts, cells that synthesize new bone. With the recent advances in scaffold and biomaterial technology as well as stem cell manipulation and transplantation, stem cells and their scaffolds are uniquely positioned to bring about significant improvements in the treatment and outcomes of spinal fusion and other injuries.

Keywords: mesenchymal stem cell, osteogenesis, scaffolds, bone morphogenetic protein, Wnt, autograft, osteoblast

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