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Statin use and its potential therapeutic role in esophageal cancer: a systematic review and meta-analysis

Authors Zhou C, Zhong X, Gao P, Wu Z, Shi J, Guo Z, Wang Z, Song Y

Received 8 November 2018

Accepted for publication 30 April 2019

Published 19 June 2019 Volume 2019:11 Pages 5655—5663

DOI https://doi.org/10.2147/CMAR.S193945

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Andrew Yee

Peer reviewer comments 2

Editor who approved publication: Dr Rituraj Purohit


Cen Zhou,* Xi Zhong,* Peng Gao, Zhonghua Wu, Jinxin Shi, Zhexu Guo, Zhenning Wang, Yongxi Song

Department of Surgical Oncology and General Surgery, The First Hospital of China Medical University, Shenyang 110001, People’s Republic of China

*These authors contributed equally to this work

Purpose: Statins, known as inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG CoA) reductases, are designed to treat lipid disorders, especially hypercholesterolemia. Apart from their role in preventing heart diseases in patients with high cholesterol, recent evidence suggests that statins have anti-tumor properties. However, studies assessing the association between statin use and esophageal cancer survival outcomes have provided controversial results.
Methods: We conducted a systematic review and meta-analysis focusing on studies evaluating associations between statin use and survival outcomes for esophageal cancer patients.
Results: A total of five cohort studies comprising 24,576 patients were included. Statin use associated with improved overall survival (OS: HR 0.84, 95% CI, 0.75–0.94) and disease-free survival (DFS: HR 0.84, 95% CI, 0.75–0.96) of esophageal cancer patients. The improved survival outcomes were consistent in the esophageal adenocarcinoma subgroup and the esophageal squamous cell cancer subgroup.
Conclusion: A potential therapeutic role of statins in esophageal cancer has been demonstrated in our study, however, the results should be interpreted cautiously and need further confirmation by future studies.

Keywords: statins, esophageal cancer, survival outcome, drug repositioning

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