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State of Emotional Health Disorders of Undergraduate Students in the United Arab Emirates: A Cross-Sectional Survey

Authors Al Marzouqi AM , Otim ME , Alblooshi A, Al Marzooqi S, Talal M, Wassim F

Received 25 March 2022

Accepted for publication 30 May 2022

Published 7 June 2022 Volume 2022:15 Pages 1423—1433

DOI https://doi.org/10.2147/PRBM.S365012

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Igor Elman



Amina M Al Marzouqi,1 Michael Ekubu Otim,1 Ahmed Alblooshi,2 Suad Al Marzooqi,3 Marah Talal,1 Farah Wassim4

1College of Health Sciences, University of Sharjah, Sharjah, United Arab Emirates; 2Ministry of Health and Prevention, Fujierah Hospital, Fujierah, United Arab Emirates; 3College of Medicine, United Arab Emirates University, Al Ain, United Arab Emirates; 4Saudi German Hospital Group, Dubai, United Arab Emirates

Correspondence: Michael Ekubu Otim, Tel +97165057527, Email [email protected]

Introduction: The emotional health disorders are a significant burden to the health of the residents of the United Arab Emirates (UAE). However, there is a paucity of evidence on the prevalence of mental health disorders throughout the Middle East in general. The prevalence of mental health problems among students and the associated impact on UAE society requires more exploration. Building an understanding of these factors is essential to inform the development of interventions in the UAE context.
Aim: This study aimed to establish the prevalence of three main mental health problems (depression, anxiety, and stress disorders) among undergraduate students in the UAE.
Methods: This study used a descriptive, cross-sectional mixed methods design. Data were collected 2018 using the Depression Anxiety Stress Scales (DASS) just before the Mental Health problems associated with Corona Pandemic and analyzed using the Statistical Package for the Social Sciences (SPSS) software.
Results: The results were reported using descriptive statistics. This study received ethical approval. The prevalence rates of depression, anxiety, and stress among university students in one Emirates in UAE were 38% (95% confidence interval [CI]: 2.04– 2.33), 55% (95% CI: 2.52– 2.87), and 29% (95% CI: 1.76– 2.02), respectively.
Conclusion: Anxiety disorders are the predominant mental health problem among UAE students. There is a need for increased research in this area and on mental health problems in general in the UAE.

Keywords: mental health, depression, anxiety disorders, stress disorders, emotional health

Introduction

Mental health encompasses emotional, psychological, and social well-being and affects how we think, handle challenges, feel, and make choices.1 Mental well-being is essential at every stage of life, from childhood and adolescence through older adulthood. Good mental health allows people to realize their full potential, cope with life stressors, be productive at their workplaces, and make meaningful contributions to their communities.2 Therefore, supporting mental health is necessary for a healthy society. However, the burden of mental health disorders is continuing to grow worldwide and has significant impacts on health and social well-being, human rights, and economic consequences globally.3

There are numerous causes of mental health challenges, including family history, violence in homes and communities, and broader issues such as war or international conflicts. Common mental health challenges include depression, posttraumatic stress disorder (PTSD), schizophrenia, anxiety, and stress disorders. However, depression, anxiety, and stress are the most common forms of mental illness. For example, depressive disorders are the fourth leading cause of the global disease burden, affecting an estimated 450 million people worldwide and causing a significant amount of disability.4 The burden of illness attributable to mental health in general is ranked second, behind ischemic heart disease.4 A systematic review5 revealed that approximately one in five respondents (18%, 95% confidence interval [CI]: 16.3–18.9%) were identified as having had a common mental disorder during the 12-month preceding assessment, and around 29% (95% CI: 25.9–32.6%) had experienced a common mental disorder at some time in their lives. The same review also revealed gender imbalances in the prevalence of common mental disorders, with women experiencing higher rates of these disorders. There was also evidence of consistent regional variation in the prevalence of common mental disorders within countries. For example, countries in North and Southeast Asia had consistently lower 1-year and lifetime prevalence estimates compared to other regions.

In the Arab world, it is estimated that approximately 17.7% of the population suffers from depression.6 However, these numbers may be an underestimate, as stigma toward mental illness in Arab societies causes many people to avoid seeking help from mental health services. This is of particular concern, as many populations in the Middle East are affected by conflict and war, meaning vulnerable groups are at high risk for PTSD, depression, anxiety, and other mental health problems.7 Other populations in the Middle East region at risk for mental health problems are “blue collar” migrant workers and expatriates. These workers are generally without health insurance coverage and include domestic maids who often work under poor conditions.7

Mental health disorders contribute to the mental health burden in the United Arab Emirates (UAE). However, there are very few studies done on the prevalence of mental health disorders throughout the Middle East, partly due to social stigma associated with mental health. The prevalence of mental health problems among students and the associated impact on UAE society have not yet been explored. Building an understanding of these factors is important to inform the development of interventions that work in the UAE context.

There is a paucity of evidence from research on mental health in the UAE and the Middle East in general. However, available data indicate there has been an alarming increase in mental illness in the region. For example, depressive, addictive, stress-related, and anxiety disorders, along with childhood behavioral problems such as attention deficit hyperactivity disorder, are increasingly common, along with psychotic disorders such as schizophrenia8. Recent WHO statistics indicated UAE estimates of the prevalence and incidence of mental health disorders were consistent with global estimates. However, these estimates and projections do not reflect the extent of the problem. Despite the UAE’s financial resources and established mental health legislation, the resources allocated to the mental health sector are modest compared with the prevalence of mental health disorders. Mental health is also a neglected area of research in the UAE and many other Arab countries. For example, between 1989 and 2008, only 192 studies on mental health in Gulf Cooperation Council countries were published, with the UAE being the most prolific in terms of research volume.9

It is widely recognized that depression and stress are likely to progress to chronic diseases or vice-versa. A study conducted among people with diabetes in Sharjah found a strong correlation between mental health status and diabetic complications, with patients with depressive symptoms having inadequate self-care, more severe physical symptoms, and lower adherence to prescribed care regimens than those without these symptoms.10 These findings suggest that improving mental health as part of comprehensive patient management plans for diabetes may improve the overall long-term outcomes for these patients.10

Students and young people are also affected by mental health problems. However, there is a paucity of data in the Middle East for this population. Students face many challenges related to their studies, such as the burden of exams and assignments, lack of sleep, and concerns about future employment, society’s expectations, and higher studies.11 Research suggests there is a high prevalence of depression, anxiety, and stress symptoms among students. For example, a study involving secondary school girls in the Kingdom of Saudi Arabia (KSA) showed that 73% had symptoms of at least one of three studied disorders (depression, anxiety, and stress) and 50% had symptoms of at least two disorders.11 That study reported that the prevalence of depression was 42%, that of anxiety was 66%, and that of stress was 53% among participating students. Students’ scores for depression, anxiety, and stress were also positively and significantly correlated; however, no significant association was found between students’ sociodemographic characteristics and scores for the three studied disorders.10 Another study involving university students from Turkey found similar prevalence rates of depression, anxiety, and stress (27%, 47%, and 27%, respectively), although anxiety and stress scores were higher among female students than male students.10 The study also showed that first- and second-year students had higher depression, anxiety, and stress scores than other students. However, students who were satisfied with their academic performance had lower depression, anxiety, and stress scores than those who were not satisfied.8,12

In general, UAE culture does not encourage individuals to express emotions publicly. Mental health professionals therefore need to be trained in how to handle patients in this context, encourage clients to express their emotions, and understand how they impact their overall well-being. The literature highlights the need to identify people experiencing mental health problems rather than waiting for them to access services. However, major obstacles include identification of such illnesses and reluctance to seek mental health support. People experiencing mental illness should be encouraged to ask for help. This means they must have access to effective and appropriate services and robust mental health policies focused on protecting and helping them. However, more than 40% of countries throughout the world do not have policies on mental health. Further, 30% of these countries do not have effective programs for mental health.2 This implies that many people may not receive the mental health assistance they may need. In addition, issues such as stigma mean that people may not receive the necessary social support.

There is, therefore, a need for customized sets of efficient interventions to be identified and implemented. In public health, for example, identifying such interventions should involve the community. In those communities where cultural barriers may prevent specific effective interventions from being considered, working with the community elders may open doors to introducing such interventions. Another issue is inadequate human resources for mental health. Some Arab regions have only one psychiatrist per 1 million people. A possible solution is to educate and train primary care and family physicians to recognize and treat common psychiatric disorders. However, before such solutions are adopted, it is important to build an accurate understanding of the prevalence and impact of mental health problems in relation to specific target groups, such as students.

This study therefore aimed to clarify the prevalence of common mental health problems (depression, anxiety, and stress disorders) among undergraduate students in the UAE using a certified international measuring survey instrument called the Depression Anxiety Stress Scales (DASS). We focused on university students, as this group is considered to represent the country’s future. In particular, we targeted undergraduate students at the university where we did the study. It is expected that the findings will provide decision-makers with evidence as to the extent of mental health problems among undergraduate students in the UAE. We also aimed to clarify correlations between students’ sociodemographic characteristics and the prevalence of depression, anxiety, and stress disorders, which may help in developing targeted interventions.

Methods and Materials

This study used a descriptive cross-sectional design to measure depression, anxiety, and stress among university students. The data were analyzed using mixed methods. The study took place in 2018, just before the COVID-19 Pandemic. Data collection lasted a couple of weeks.

Ethical Considerations

This study involved humans and therefore conducted with accordance with the principles of the Declaration of Helsinki. This study received ethical approval from The University Sharjah Research Ethics Committee (REC), approval number: REC- 18-03-18-01-RS. Informed Consent Form to participate in the study was submitted to the Research Ethics Committee for approval in both English and Arabic. All participants read the informed consent form and signed before participating in the study. Participation was voluntary and respondents were free to pull out of the study any time if they so chose. The University Ethics Committee were advised that the data collection and study findings would be published according to the ethical guidelines from the UOS. The students were therefore free not to participate or free to pull out at any time.

Population and Sample

University of Sharjah (UOS) Study participants were first- through fourth-year undergraduates. We excluded students completing higher degree studies as well as diploma/higher diploma students. UOS had about 13,000 students in 2018 and all had equal chance to be selected for the sample. We chose to exclude the students’ fields of study in t. This may constitute the study limitation.

Participants were predominantly from Arab-speaking background. English speaking students also exist since about 90% of the UAE population are non-citizens. That is why we had two versions of the DASS instrument (Arabic and English) when interviewing. Participants would be asked which language they preferred to use for the interview. We did not however seek to identify their nationalities, except for the

A non-probability convenience sampling technique was used without consideration of gender or students’ rank stratification. However, the sampling technique was not wholly based on convenience sampling because of cultural sensitivity and the survey tool, which contained diagnostic questions. Students deeply involved in work activities, or in upcoming examinations to ensure the reliability, privacy, and confidentiality of the data. The required sample size was calculated at approximately 300 students using Statistical Epi-Info 7.13 In total, 340 students across three campuses were invited to participate. Surveys were excluded if a participant had skipped more than four questions because of the influence of missing data on reliability. We also excluded surveys where sociodemographic and personal characteristics had not been provided.

Data Collection Instrument

Self-reported data were collected using the DASS.14 The DASS includes 42 short diagnostic statements that assess depression, anxiety, and stress symptoms. Arabic and English versions of the paper-based DASS survey instrument were administered to participants at the university. These two versions of the DASS instruments have been tested and retested for validity and reliability in Arabic language.15 We used both English and Arabic questionnaires. Participants were asked to rate each statement based on their emotional status and how frequently they had experienced these feelings during the past week. Responses are on a four-point scale from 0 (“did not apply to me at all”) to 3 (“applied to me very much”).

When providing study information, particularly the informed consent to the participants, the research team emphasized that the study focused on the vocabulary “students’ emotional wellbeing of the students” rather than the “mental health” status per se, because of the widespread cultural stigma towards mental illness in Arab societies. In addition, the research team added a sheet collecting sociodemographic characteristics to the DASS to allow correlation analyses.

Scoring Method

The 42 DASS items were aggregated for each category to obtain total scores for depression, anxiety, and stress disorders. A rating scale was then used to classify these scores as “standard,” “mild,” “moderate,” “severe,” or “too severe.” According to the DASS manual, a standard score for the three disorders is considered “no symptoms at all.” A classification of “mild” is considered to indicate the onset of a disorder, but the individual is not eligible to seek help. Therefore, we considered scores of “moderate,” “severe,” and “too severe” as reflecting the presence of that disorder and based our analysis and interpretation on this classification.

Data Analysis

Data were coded, cleaned, and analyzed using SPSS version 22.0.16 A unified number was used for coding each survey package, which contained a consent form, the DASS, and the additional variable sheet. The scoring sheet was then separated for storage and kept secure to ensure confidentiality and safety. Data were analyzed, and results were presented using descriptive statistics, including frequencies, percentages, means, modes, standard deviations, and other statistical tests, as relevant.

Results

The main aim for this study was the examine the prevalence of depression, anxiety, and stress among undergraduate university students. The results primarily show the descriptive statistics for depression, anxiety, and stress among participating students. We found that the prevalence of depression was 38%, that of anxiety was 55%, and that of stress was 29% (Table 1). Anxiety was the dominant disorder or negative emotional state among participants, followed by depression. The mean score from the four point scale for depression was 2.18 (95% CI: 2.04–2.33), that for anxiety was 2.69 (95% CI: 2.52–2.87), and that for stress disorders was 1.89 (95% CI: 1.76–2.02). The histogram for the three disorders was positively skewed (ie, toward no or mild disorders). In addition, the median scores for depression, anxiety, and stress were 2, 3, and 1, respectively. The median is considered a descriptive measure that works well for skewed data or data with outliers. We found that the median score for anxiety (median: 3) was closer to a normal distribution than that of the other two disorders, which showed more skewness (depression: 1.054, stress: 0.761).

Table 1 Descriptive Statistics for Depression, Anxiety and Stress

The correlations between participants’ socio-demographic characteristics and prevalence of depression, anxiety, and stress are shown in Table 2. Overall, we found that the prevalence of depression was 38%, that of anxiety was 55%, and that of stress was 29%. Anxiety was the dominant disorder or negative emotional state among participants, followed by depression. We found that anxiety was the dominant negative emotional state across all characteristics. There was no significant difference in depression between males and females. However, compared with males, more females reported anxiety (61% vs 47%) and stress (32.2% vs 24.4). The results also showed higher rates of all three negative emotional states in students aged 17–21 compared with those aged 22–26 (depression: 38.5% vs 37.2%; anxiety: 57.6% vs 50%; stress: 29.5% vs 28.6%). Compared with self-paid students, more scholarship students reported anxiety (64.4% vs 53.6%) and depression (40% vs 37%), but fewer reported stress (24.4% vs 29.7%). Interestingly, there was little difference in anxiety between UAE nationals and non-nationals. We found lower prevalence rates of all three negative emotional states among students who lived off campus compared with those who lived on campus or with family. Anxiety was particularly high among students living on campus (64.3%). Overall, anxiety affected the largest number of students across all years of study (Table 2). Anxiety was the highest in the first year (61.7%), before falling in the subsequent two years and then rising again in the fourth year, although this remained lower than in the first year at 58.3%.

Table 2 Cross Tabulation of Socio-Demographics with the Negative Emotional Disorders

We also found that students with pre-existing health conditions were more likely to be affected by anxiety and stress than those without pre-existing health conditions (Table 3). Relative risk (RR) is a measure of how exposure to specific factors may enhance the risk for developing a specific outcome. We found that students suffering from health problems had a greater RR for developing anxiety compared with depression and stress. Students with underlying health problems reported more stress than students without (Table 3) health problems (RR=1.790). Overall, the RRs for depression (0.941) and anxiety (1.172) showed weak associations with health problems. We also found that students who were unsatisfied with their academic performance reported more negative emotional states than satisfied students. Students who were satisfied with their academic performance were less depressed than unsatisfied students by 38.6% (RR 0.614). The RRs for anxiety and stress in academically satisfied students were 0.851 and 0.670, respectively, which suggests satisfaction with academic performance as a protective factor that may mitigate the onset of these disorders.

Table 3 Prevalence of Disorders According to the Students’ Personal Characteristics

There were no significant differences in the rates of depression and anxiety between students who were smokers and those who were non-smokers, although there were differences in reported severity. More smokers were classified as having “severe” or “too severe” depression than non-smokers (by 35.0%). The prevalence of stress was also higher in smokers than non-smokers (by 13.2%), with smokers also reporting greater severity of stress than non-smokers (by 18.6%). The RRs for depression (1.0) and anxiety (0.994) were lower than those for stress (1.19), which showed a slight positive association with smoking.

Discussion

This study showed that anxiety was the most prevalent of the three mental health problems studied, which was consistent with findings from KSA and Turkey.11,12 It is important to conduct further studies in the region to understand why there is such a high prevalence of anxiety. Further qualitative and quantitative research is also important to build understanding of mental health problems in general among students and other populations in the region. Stress was the second most common disorder among students. This was similar to findings from KSA11 but differed from the Turkish study.12 Interestingly, although stress was common in our study population, it showed the lowest mean score (1.89) compared with anxiety (2.69) and depression (2.33). Our correlation analysis showed that depression and anxiety were more common than stress across all sociodemographic characteristics.

The study results showed no significant differences in depression between males and females, although more females reported experiencing anxiety and stress than males. In addition, more females were classified as “severe” and “too severe” than males in all three disorders, with the difference being 50%, 56%, and 72% for depression, anxiety, and stress, respectively (data not shown). Our results can be compared to the findings in the literature, which indicate that females have a higher RR of developing depression than men. This is mainly due to biological differences and socioeconomic issues.17 However, it should be noted that our sample included significantly fewer male participants than female. Furthermore, participating students aged 17–21 showed a higher prevalence of all three disorders compared with those aged 22–26. More local students were classified as having “severe” or “too severe” anxiety (37%) compared with students from other nationalities (26%). In a systematic review, Razzak et al reported that their results revealed that medical students were more prone to depression than other university students (28.6% and 22.2%, respectively).18

Compared with self-paid students, more students who studied under the scholarship program reported depression and anxiety, although they had lower stress than self-paid students. The majority of the national students had scholarships from the government based on a GPA above 2.0. A reduction in their GPA would put scholarship students at risk of losing those scholarships. It is likely that this is the cause of the severity of depression. Our finding that students who lived on campus showed a higher prevalence of all three disorders compared with those who lived off campus may be related to financial stability. For example, those living off campus could afford to rent accommodations outside the university. Anxiety was the dominant disorder in students from all three residential categories (on campus 64.3%; with family 53%; off campus 40.0%). Our findings indicate that students who lived on campus or with family showed higher levels of anxiety than those living off campus. Freedom from restrictions in the dormitory or with family may lower level of anxiety. This warrants further investigation.

More first-year students developed anxiety than students in other years (61.7%), although second-year students had the most negative emotional state overall compared with students from other years. There was a steady increase in the severity from the first to the third year, followed by a slight decline in the final year. Anxiety is high in the first year probably because of the new education stage, and uncertainty about what all that entails. However, there is also a lot of pressure with regard to studies and expectations of scores and graduation-related issues for fourth-year students. Interestingly, more third-year students reported stress and depression than students in other years. This could be because of their performance in the previous two years and starting major courses, including clinical and field training.

This study showed that students suffering from health issues had a greater RR for developing anxiety compared with depression or stress. More students with health problems reported stress than those without health problems. However, the RRs for depression (0.941) and anxiety (1.172) showed weak associations with health problems. We also found more depression, anxiety, and stress among students who were unsatisfied with their academic performance compared with satisfied students. In particular, students who were satisfied with their academic performance showed less depression (RR 0.614), anxiety (RR 0.851), and stress (RR 0.670) than unsatisfied students who might have low self-esteem. These findings suggest satisfaction with academic performance as a protective factor that may mitigate the onset of these three disorders. Despite our finding of no differences in rates of depression and anxiety between smokers and non-smokers, there were differences in reported severity with more smokers classified with “severe” or “too severe” depression compared with non-smokers. In addition, the prevalence and severity of stress was higher in smokers than in non-smokers.

The implication from this study include the following: Research shows that the prevalence and incidence of mental illnesses are not going to decrease.18 It is therefore important that Arab countries deal with these challenges by increasing available funding and providing adequate healthcare services to address mental health. There is a need for comprehensive public mental health campaigns to mitigate the spread of mental health problems by targeting mental health-specific vulnerabilities and non-communicable diseases that tend to be associated with mental illnesses.

The UAE has placed mental health on the national health agenda, with the goal of improving health outcomes for the UAE population.19 The government has also developed key performance indicators for the healthcare sector to address mental illness and is actively implementing measures to address mental health issues and reduce the associated stigma. Many initiatives have been implemented for residents, including access to mental health services, and support as required. This calls for a comprehensive and coordinated mental health policy at the UAE level.

Within the framework of supporting and empowering patients with mental health problems, the UAE has specialized curative and awareness programs. In addition, young doctors are trained on innovative approaches using virtual reality experiences in medicine. Innovative digital solutions in the mental health field have also been implemented to enhance prevention and early detection programs. A comprehensive national statistical database for mental health is also planned to support health-related scientific research, studies, and publications.

The UAE National Policy for the Promotion of Mental Health specifies several strategic initiatives to strengthen services and promote awareness of mental health.20 However, there is a need for the training of primary care general practitioners and family physicians to provide early intervention and sustainability of mental health services.

To support these policy objectives and build on our findings, there is an urgent need for evidence on how stigmatization, community acceptance, and other cultural barriers can be addressed to contribute to a positive mental health experience for students and the general public. It is hoped that this study will support universities and students’ guardians in understanding the extent of issues such as depression, anxiety, and stress among students. Our findings may also help families and universities identify students struggling with mental health problems and provide solutions that contribute to addressing these issues.

Our study had some limitations that should be considered. A key limitation of this study was that the stigma attached to mental health in Arab societies might have caused students to be hesitant about participating in this study or responding to the DASS items. However, to avoid stigma influencing participation and responses, we rephrased the study information to emphasize that the focus was on studying emotions rather than mental health status per se.

The key limitation of this study is that its population was from one university. It is difficult to place it in the context of other universities in the UAE and the Middle East in general. Being a cross-sectional study, it can only be used for descriptive purposes but cannot be generalized. This calls for more research and support through the establishment and strengthening of government policies that protect and allow open discussion of mental health. However, it gives an overview of the state of mental health in the Middle East, where such illness is often stigmatized.

Conclusions

We found relatively high rates of depression, anxiety, and stress among university students. Anxiety was the dominant disorder across different demographic and personal characteristics. However, other disorders are also significant in terms of severity among students experiencing these disorders. These results apply to this sample and target population only, and it is necessary to expand this study to include other universities in UAE. Decision-makers at the university should consider the results of this study when planning students’ health initiatives and remain conscious of the effect of university policies on students’ mental health. Furthermore, universities in the UAE should offer professional help to students by hiring licensed psychologists and counselors to help students with psychological problems.

Social stigma toward mental illness prevents individuals from seeking medical help or talking about mental health needs to family and psychologists. Awareness is the first step in confronting stigma, and it is what we hope to achieve from this research. We also hope that this research encourages relevant authorities to redirect attention and resources to addressing human resources for mental health. Knowing that the prevalence of mental illnesses is high will likely encourage governments to invest in cost-effective interventions.

Abbreviations

DASS, Depression Anxiety Stress Scales; PTSD, Post Traumatic Stress Disorder; SPSS, Statistical Package for the Social Sciences; REC, Research Ethics Committee; UAE, United Arab Emirates; KSA, Kingdom of Saudi Arabia.

Data Sharing Statement

Please contact the corresponding author for data requests.

Ethics Approval and Consent to Participate

This study involved humans and therefore conducted with accordance with the principles of the Declaration of Helsinki. This study received ethical approval from The University Sharjah Research Ethics Committee (REC), approval number: REC- 18-03-18-01-RS. Informed Consent Form to participate in the study was submitted to the Research Ethics Committee for approval in both English and Arabic. All participants read the informed consent form and signed before participating in the study. Participation was voluntary and respondents were free to pull out of the study any time if they so chose. The University Ethics Committee were advised that the data collection and study findings would be published according to the ethical guidelines from the UOS. The students were therefore free not to participate or free to pull out at any time.

Consent for Publication

The participants were advised that the purpose of the interviews was to publish and disseminate the results following ethical guidelines. The students were therefore free not to participate or pull out at any time. The Ethics Committee was advised that the findings would be published. The Committee was happy for the study to be conducted according to the Research Protocol submitted for consideration and no changes to the protocol were needed for the study.

Acknowledgments

We would like to thank all the participants.

Author Contributions

All authors contributed to data analysis, drafting, or revising the article; agreed on the journal to which the article was submitted; gave final approval of the version to be published; and agreed to be accountable for all aspects of the work.

Funding

No funding was received for this study from any source.

Disclosure

The authors report no conflicts of interest in relation to this work and declare that this research was conducted in the absence of any commercial or financial relationships that could be construed as potential conflicts of interest.

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