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Spotlight on pembrolizumab in the treatment of advanced melanoma

Authors Rajakulendran T, Adam D

Received 19 April 2015

Accepted for publication 19 May 2015

Published 4 June 2015 Volume 2015:9 Pages 2883—2886

DOI https://doi.org/10.2147/DDDT.S78036

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Professor Shu-Feng Zhou


Thanashan Rajakulendran,1 David N Adam2

1Department of Medicine, Division of Dermatology, Postgraduate Medical Education, 2Department of Medicine, Division of Dermatology, St Michael’s Hospital, University of Toronto, Toronto, ON, Canada

Abstract: Metastatic melanoma is an aggressive cancer with a poor prognosis. Many approved therapies often do not achieve durable responses in patients. This underscores the need for novel therapeutic strategies. Recruiting a robust immune response is an important antineoplastic treatment strategy. Immune checkpoints offer a molecular target for modulating the immune response and a promising therapeutic target in metastatic melanoma. Here we discuss the recent approval of pembrolizumab by the US Food and Drug Administration for the treatment of metastatic melanoma and its impact on future management of the disease.

Keywords: pembrolizumab, melanoma, immune checkpoint, PD-1, PD-L1

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