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Spontaneous-timed versus controlled noninvasive ventilation in chronic hypercapnia – a crossover trial

Authors Kerl J, Höhn E, Köhler D, Dellweg D

Received 14 October 2018

Accepted for publication 18 February 2019

Published 8 May 2019 Volume 2019:12 Pages 173—181

DOI https://doi.org/10.2147/MDER.S190841

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Amy Norman

Peer reviewer comments 2

Editor who approved publication: Dr Scott Fraser


Jens Kerl, Ekkehard Höhn, Dieter Köhler, Dominic Dellweg

Department for Pulmonary Medicine, Intensive Care Medicine and Sleep Medicine, Fachkrankenhaus Kloster Grafschaft GmbH, Schmallenberg, 57392, Germany

Background: There is an ongoing debate about optimal ventilator modes and settings during noninvasive ventilation (NIV).
Objectives: To compare the effect of spontaneous-timed (ST) and controlled NIV on carbon dioxide reduction in patients suffering from chronic hypercapnia.
Methods: Night and daytime blood gas analysis, lung function tests and 6 minute walking distance tests (6MWD) were done before and after every 6-week treatment.
Results: This randomized prospective crossover trial included 42 patients. Pooled data analysis showed a decrease of nocturnal CO2 from 54.8±5.9 mmHg to 41.6±5.5 mmHg during ST ventilation (p<0.01) and from 56.2±7.5 mmHg to 42.7±5.4 mmHg during controlled NIV (p<0.01) with no difference between treatment forms (p=0.30). Daytime CO2 levels decreased from 49.3±5.5 mmHg to 45.6±4.5 mmHg when spontaneous timed ventilation was applied (p<0.01) and from 52.2±6.8 mmHg to 44.9±21114.4 mmHg in case of controlled ventilation (p<0.01) The amount of CO2 reduction was 3.8±5.6 mmHg after ST mode and 7.3±6.8 mmHg controlled ventilation (p<0.05). Nocturnal ventilator use was 5.7±2.1 and 6.7±2.3 hours for ST and controlled ventilation respectively (p=0.02). There was no effect on walking distance and lung function.
Conclusion: Controlled NIV showed improved compliance compared to ST ventilation. We observed similar CO2 reductions during nocturnal ventilation, however controlled ventilation achieved a higher reduction of daytime CO2 levels.

Keywords: noninvasive mechanical ventilation, clinical trials, respiratory failure, reversible hypercapnia, ventilator mode, controlled ventilation

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