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Spinal nerve injury causes upregulation of ErbB2 and ErbB3 receptors in rat dorsal root ganglia
Authors Mizobuchi S, Kanzaki H, Omiya H, Matsuoka Y, Obata N, Kaku R, Nakajima H, Ouchida M, Morita K
Received 30 November 2012
Accepted for publication 28 December 2012
Published 4 February 2013 Volume 2013:6 Pages 87—94
DOI https://doi.org/10.2147/JPR.S40967
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Satoshi Mizobuchi,1* Hirotaka Kanzaki,1–3* Hiroki Omiya,1 Yoshikazu Matsuoka,1 Norihiko Obata,1 Ryuji Kaku,1 Hirochika Nakajima,1 Mamoru Ouchida,2 Kiyoshi Morita1
1Department of Anesthesiology and Resuscitology, 2Department of Molecular Genetics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan; 3Cedars-Sinai Medical Center, Los Angeles, USA
*These authors contributed equally to this work
Abstract: It is generally known that peripheral nerve injury causes changes in expression of some growth factors in the dorsal root ganglion. Altered expression of ErbB receptors, a well-known growth factor in somatic cells, reportedly follows peripheral nerve injury in the spinal dorsal horn; however, it remains unknown whether the expression of these receptors is altered in the dorsal root ganglion after nerve injury. Therefore, this study examined the gene expression profiles of ErbB receptors in bilateral lumbar (L)4/L5 dorsal root ganglia, using L5-selective spinal nerve ligation in model rats as a peripheral nerve injury model. The expression of ErbB2 and ErbB3 was observed in the dorsal root ganglia of the mature rat, despite ErbB1 and ErbB4 showing only subtle expression. We also demonstrated that peripheral nerve injury induced significant increases in ErbB2 and ErbB3 in the ipsilateral dorsal root ganglion as compared with uninjured nerve. Expression changes in ErbB receptors appear to play important roles in nerve injury and subsequent nerve regeneration.
Keywords: DRG, spinal nerve ligation, SNL
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