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Spinal cord demyelination combined with hyperhomocysteinemia: a case report

Authors Hao MM, Zhang Y, Hou SX, Chen YL, Shi M, Zhao G, Deng YC

Received 11 July 2014

Accepted for publication 23 September 2014

Published 3 November 2014 Volume 2014:10 Pages 2057—2059

DOI https://doi.org/10.2147/NDT.S70963

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Dr Roger Pinder

Meimei Hao, Yan Zhang, Shuangxing Hou, Yanling Chen, Ming Shi, Gang Zhao, Yanchun Deng

Department of Neurology, Xijing Hospital, Fourth Military Medical University, Xi’an, People’s Republic of China

Abstract: Hyperhomocysteinemia (HHcy) has been recognized as an independent risk factor for atherosclerotic vascular disease. Here we report a patient who suffered from spinal cord demyelination combined with HHcy. The patient was admitted to our hospital with a diagnosis of acute myelitis. However, hormone therapy was ineffective. Further investigations revealed that he had HHcy and a homozygous mutation of the gene encoding methylenetetrahydrofolate reductase (MTHFR) c.677C>T, which is a key enzyme involved in homocysteine metabolism. In view of these findings, we treated the patient with B vitamins and his symptoms gradually improved. Spinal magnetic resonance imaging performed 3 months after onset showed near recovery of the lesion. To our knowledge, similar reports are rare.

Keywords: demyelination, hyperhomocysteinemia, homocysteine, methylenetetrahydrofolate reductase, methylation

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