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Sphingosine-1-phosphate signaling as a therapeutic target

Authors Giannoudaki, Swan, Kirby, Ali S

Received 19 May 2012

Accepted for publication 1 June 2012

Published 11 July 2012 Volume 2012:4 Pages 63—72

DOI https://doi.org/10.2147/CHC.S34014

Checked for plagiarism Yes

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Eirini Giannoudaki, David J Swan, John A Kirby, Simi Ali

Applied Immunobiology and Transplantation Research Group, Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK

Abstract: Sphingosine 1-phosphate (S1P) is a small bioactive lipid molecule that is involved in several processes both intracellularly and extracellularly. It acts intracellularly to promote the survival and growth of the cell, through its interaction with molecules in different compartments of the cell. Extracellularly, it can exist at high concentrations in the blood plasma and lymph, further down inside the tissue. This causes an S1P gradient important for cell migration. S1P signals through five G protein-coupled receptors, S1PR1–S1PR5, whose expression varies in different types of cells and tissue. S1P signaling can be involved in physiological and pathophysiological conditions of the cardiovascular, nervous, and immune systems and diseases such as ischemia/reperfusion injury, autoimmunity, and cancer. In this review, we discuss this involvement and how it can be used to discover novel therapeutic targets.

Keywords: S1P, CD69, T-cell activation, lymph node, recirculation

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