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Sorafenib in metastatic MTC – a case report and minireview of the literature

Authors Petrova M, Mihaylova Z, Fakirova A

Published 27 May 2010 Volume 2010:3 Pages 55—58

DOI https://doi.org/10.2147/IMCRJ.S9384

Review by Single anonymous peer review

Peer reviewer comments 2

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Mila Petrova1, Zhasmina Mihaylova1, Albena Fakirova2

1Hematology and Oncology Department, 2Pathology Department, Medical Military Academy, Sofia, Bulgaria

Abstract: Medullary thyroid cancer (MTC) is a rare and only surgically treatable disease with early development of metastases and bad prognosis. Due to the lack of efficient systemic treatment, new strategies and approaches are needed to better the patients’ outcome. One of the most promising treatment options is the use of tyrosine multikinase inhibitors, which appear to have some effect on the disease progression with tolerable toxicity. Most of them affect many key pathways in the cancer genesis and have proven their effect in different malignancies. We report a case of a young patient with metastatic MTC treated successfully for two months with sorafenib.

Keywords: medullary thyroid cancer, tumor response, cardiotoxicity, TKIs

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