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Sonidegib, a novel smoothened inhibitor for the treatment of advanced basal cell carcinoma

Authors Doan H, Silapunt S, Migden M

Received 10 March 2016

Accepted for publication 7 June 2016

Published 14 September 2016 Volume 2016:9 Pages 5671—5678

DOI https://doi.org/10.2147/OTT.S108171

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Manfred Beleut

Peer reviewer comments 3

Editor who approved publication: Dr Faris Farassati


Hung Q Doan,1 Sirunya Silapunt,1 Michael R Migden2,3

1Department of Dermatology, University of Texas, McGovern Medical School, 2Mohs Surgery Unit, Department of Dermatology, 3Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

Abstract: Basal cell carcinoma (BCC) is the most common nonmelanoma skin cancer. If left untreated, BCCs can become locally aggressive or even metastasize. Currently available treatments include local destruction, surgery, and radiation. Systemic options for advanced disease are limited. The Hedgehog (Hh) pathway is aberrantly activated in a majority of BCCs and in other cancers. Hh pathway inhibitors are targeted agents that inhibit the aberrant activation of the Hh pathway, with smoothened being a targeted component. Sonidegib is a novel smoothened inhibitor that was recently approved by the US Food and Drug Administration. This review focuses on BCC pathogenesis and the clinical efficacy of sonidegib for the treatment of advanced BCC.

Keywords: nonmelanoma skin cancer, Hedgehog pathway, clinical trials

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